Antagonistic joint toxicity assessment of two current-use phthalates with waterborne copper in liver of Carassius auratus using biochemical biomarkers

Ecotoxicology and Environmental Safety
Boyang HuangYan Yang

Abstract

Di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP) are two kinds of widely-used phthalates, whereas Cu (II) is a common valence state of copper. They have been ubiquitously detected in the aquatic environment, but information on their joint toxicity on aquatic organisms is scarce. In this study, we evaluated the combined effects of copper and these two phthalates to the goldfish (Carassius auratus) by detecting the antioxidant responses in liver after exposure for 7 and 21 days. The exposure concentrations were in a range relevant to their levels in the natural aquatic environment. The results indicated that DBP, DEHP and Cu (II) can affect the antioxidant status in fish liver, evidenced by the significant alterations of antioxidant defenses (superoxide dismutase, catalase, glutathione) and malondialdehyde. Antagonistic effects were found in the joint toxicity of Cu (II) and DBP or DEHP using the integrated biomarker response (IBR) index. These findings have important implications in the risk assessments of phthalates mixed with some heavy metals in the aquatic environment.

References

Feb 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Góth
Dec 1, 1990·Biochemical Society Transactions·P Di MascioH Sies
Jan 1, 1989·Free Radical Research Communications·T Bigwood, G Read
Aug 10, 2000·European Journal of Biochemistry·R Dringen
Aug 10, 2000·European Journal of Biochemistry·J B SchulzJ Dichgans
Aug 15, 2000·Journal of Pediatric Gastroenterology and Nutrition·M OlivaresR Uauy
Jun 8, 2001·Human Reproduction Update·P M FosterM Sar
May 9, 2002·Water Research·Hermann FrommeAndrea Wenzel
Jun 19, 2002·Environmental Toxicology and Chemistry·Benoit Beliaeff, Thierry Burgeot
Jun 25, 2003·Toxicology·Lisa M Gaetke, Ching Kuang Chow
Nov 25, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Kyung Won SeoKwang Sik Choi
Sep 21, 2004·Annual Review of Plant Biology·Klaus Apel, Heribert Hirt
Aug 23, 2005·The Journal of Nutritional Biochemistry·Roberta MasellaClaudio Giovannini
Sep 25, 2007·International Journal of Hygiene and Environmental Health·Ursel HeudorfJürgen Angerer
Nov 27, 2007·Journal of Hazardous Materials·Fan WangYujuan Sha
May 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lee Macomber, James A Imlay
Jun 17, 2009·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Emma L TeutenHideshige Takada
Jul 9, 2009·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Melanie F StruveDavid C Dorman
Sep 26, 2009·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Zhi-Hua LiTomas Randak
Jul 1, 1947·Journal of the American Chemical Society·L D SMALLC J CAVALLITO
Apr 7, 2010·Chemical Communications : Chem Comm·Talib PirmohamedWilliam T Self
Sep 28, 2010·Plant Physiology and Biochemistry : PPB·Sarvajeet Singh Gill, Narendra Tuteja
Dec 14, 2011·Ecotoxicology and Environmental Safety·Maria Conceiçao VieiraAntonio Canalejo
Feb 22, 2012·Colloids and Surfaces. B, Biointerfaces·R K DuttaA V R Reddy
Apr 20, 2012·Toxicology and Applied Pharmacology·Anna A ShvedovaValerian E Kagan
Jan 1, 2013·The Science of the Total Environment·Xiaoli WuYongqiang Ma

❮ Previous
Next ❯

Citations

Jul 8, 2016·Bulletin of Environmental Contamination and Toxicology·Boyang HuangYan Yang
Feb 7, 2021·The Science of the Total Environment·Ying ZhangYang Yang
Mar 19, 2021·Ecotoxicology and Environmental Safety·Naima HamidDe-Sheng Pei

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.