Antagonistic regulation of a proline-rich transcription factor by transforming growth factor beta and tumor necrosis factor alpha.

The Journal of Biological Chemistry
A Alevizopoulos, N Mermod

Abstract

Transforming growth factor beta (TGF-beta) and tumor necrosis factor alpha (TNF-alpha) often exhibit antagonistic actions on the regulation of various activities such as immune responses, cell growth, and gene expression. However, the molecular mechanisms involved in the mutually opposing effects of TGF-beta and TNF-alpha are unknown. Here, we report that binding sites for the transcription factor CTF/NF-I mediate antagonistic TGF-beta and TNF-alpha transcriptional regulation in NIH3T3 fibroblasts. TGF-beta induces the proline-rich transactivation domain of specific CTF/NF-I family members, such as CTF-1, whereas TNF-alpha represses both the uninduced as well as the TGF-beta-induced CTF-1 transcriptional activity. CTF-1 is thus the first transcription factor reported to be repressed by TNF-alpha. The previously identified TGF-beta-responsive domain in the proline-rich transcriptional activation sequence of CTF-1 mediates both transcriptional induction and repression by the two growth factors. Analysis of potential signal transduction intermediates does not support a role for known mediators of TNF-alpha action, such as arachidonic acid, in CTF-1 regulation. However, overexpression of oncogenic forms of the small GTPase Ras or o...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Oct 1, 1992·Molecular and Cellular Biology·J L SlackP Bornstein
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G J ThorbeckeM A Palladino
Apr 1, 1990·Molecular and Cellular Biology·S J KimA B Roberts
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Oct 5, 1989·Journal of Molecular Biology·M CareyM Ptashne
Mar 2, 1989·Nature·J W Lillie, M R Green
Sep 25, 1989·Nucleic Acids Research·I Sadowski, M Ptashne
Oct 1, 1994·Current Opinion in Cell Biology·J Gailit, R A Clark
Mar 1, 1995·Trends in Biochemical Sciences·E Cano, L C Mahadevan
Dec 1, 1994·Trends in Biochemical Sciences·R Derynck
Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·M T ArmenteroN Mermod
Jul 1, 1994·The Journal of Cell Biology·R A Heller, M Krönke
Jan 28, 1994·Cell·T KishimotoS Akira
Mar 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·H KellerW Wahli
Dec 15, 1995·Genes & Development·A AlevizopoulosN Mermod
Oct 1, 1995·Trends in Cell Biology·P VandenabeeleW Fiers

❮ Previous
Next ❯

Citations

Jul 1, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Alevizopoulos, N Mermod
Mar 3, 2005·Nucleic Acids Research·Masatoshi JinninKunihiko Tamaki
Dec 30, 2011·Journal of Virology·Bo LiangWilliam R Folk
Nov 25, 2003·DNA Sequence : the Journal of DNA Sequencing and Mapping·Raymund Stefancsik, Satyapriya Sarkar
Aug 21, 2001·The Journal of Investigative Dermatology·H IhnM Trojanowska
Mar 2, 1999·Developmental Biology·Q TangD Goldowitz
Jan 19, 1999·Molecular Endocrinology·D A DeMannoM Hunzicker-Dunn
Aug 8, 1997·The Journal of Biological Chemistry·P GreenwelF Ramirez

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.