Antarctic isolation: immune and viral studies

Immunology and Cell Biology
T R TingateDuane L Pierson

Abstract

Stressful environmental conditions are a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous delayed-type hypersensitivity responses and a peak 48.9% reduction of T cell proliferation to the mitogen phytohaemagglutinin, were documented during a 9-month period of isolation. T cell dysfunction was mediated by changes within the peripheral blood mononuclear cell compartment, including a paradoxical atypical monocytosis associated with altered production of inflammatory cytokines. There was a striking reduction in the production by peripheral blood mononuclear cells of the predominant pro-inflammatory monokine TNF-alpha and changes were also detected in the production of IL-1, IL-2, IL-6, IL-1ra and IL-10. Prolonged Antarctic isolation is also associated with altered latent herpesvirus homeostasis, including increased herpesvirus shedding and expansion of the polyclonal latent Epstein-Barr virus-infected B cell population. These findings have important long-term health implications.

References

Jun 1, 1979·Psychosomatic Medicine·J PalmbladT Akerstedt
Apr 1, 1992·Journal of Interferon Research·G SonnenfeldM Montalbini
Nov 1, 1990·Psychological Bulletin·A O'Leary
Feb 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·H B BenestadO I Molvaer
Sep 1, 1988·Journal of Clinical Immunology·R MeehanR Goldblum
Apr 1, 1988·Archives of Neurology·V PurvinW De Myer
Jul 1, 1988·Clinical Microbiology Reviews·M OkanoD T Purtilo
Aug 1, 1995·Immunology and Cell Biology·H K MullerD Quinn
Apr 1, 1995·Pathology·H K MullerK Donovan
Mar 1, 1995·Brain, Behavior, and Immunity·D A SchmittE Ohayon
Nov 1, 1994·Immunology Today·J E Blalock
Nov 1, 1994·Immunology Today·C A Ottaway, A J Husband
Sep 1, 1993·Journal of Leukocyte Biology·G R Taylor
Sep 1, 1993·Journal of Leukocyte Biology·I V KonstantinovaE A Antropova
Sep 1, 1993·Journal of Leukocyte Biology·G R Taylor
Sep 1, 1993·Journal of Leukocyte Biology·D A Schmitt, L Schaffar
Jul 1, 1993·Psychosomatic Medicine·T B Herbert, S Cohen
Oct 1, 1960·The American Journal of Psychiatry·C S MULLIN

❮ Previous
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Citations

Sep 7, 2001·Acta Astronautica·D Lugg, M Shepanek
Jun 9, 1999·Journal of Affective Disorders·B H NatelsonW C Gause
Oct 9, 2002·Trends in Pharmacological Sciences·James J Olson
Jul 25, 2000·Nutrition·Y VodovotzH W Lane
Oct 4, 2002·Nutrition·Andrea T BorchersM Eric Gershwin
Feb 7, 2001·Annual Review of Psychology·P Suedfeld, G D Steel
Aug 8, 2012·Neuroimmunomodulation·Anand Prakash YadavShashi Bala Singh
Sep 16, 2010·Immunological Investigations·Kamla Prasad MishraGovindasamy Ilavazhagan
May 6, 2011·Health & Place·Christine A MairM Kristen Peek
Sep 22, 2012·Journal of Medical Virology·Raymond P StoweJames S Goodwin
May 14, 2004·Journal of Science and Medicine in Sport·M GleesonP A Fricker
Mar 1, 2007·FEMS Microbiology Ecology·Valery PolischukSvitlana Oliynik
Jul 7, 2018·Allergy·Matthias FeuereckerAlexander Choukèr
Feb 20, 2009·The American Journal of Clinical Nutrition·Scott M SmithSara R Zwart
Jan 31, 2006·International Journal of Circumpolar Health·Edward C De Fabo
Dec 15, 2000·Immunology and Cell Biology·M GleesonC A McConnell
Jul 18, 2002·Immunology and Cell Biology·J Lynn FrancisAnne Watson
Oct 9, 2002·International Journal of Circumpolar Health·Ogilvie Thom, Desmond J Lugg
Feb 6, 2016·Journal of Applied Physiology·J I Pagel, A Choukèr
Mar 7, 2002·Medicine and Science in Sports and Exercise·Maree GleesonPeter A Fricker
May 8, 2021··RAY LC, Daijiro Mizuno

❮ Previous
Next ❯

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