PMID: 3384220Apr 1, 1988Paper

Antecedent chronic hyperglycaemia blocks phlorizin-induced insulin resistance in the dog

Diabetologia
M KofflerJ H Helderman

Abstract

Hyperglycaemia may enhance insulin resistance typical of non-insulin dependent diabetes mellitus, as well as insulin dependent diabetes mellitus, and thus initiate a vicious pathogenetic cycle. We sought to test the hypothesis that reduction in chronic hyperglycaemia in the diabetic dog by methods that do not employ insulin may improve insulin resistance. We used the glucuretic agent phlorizin in dogs rendered chronically hyperglycaemic and diabetic by alloxan treatment. To analyse glucose disposition the euglycaemic clamp was performed. To minimize the role of counterregulatory influences that might be at play when glucose is reduced, the hyperglycaemic clamp with continuous somatostatin infusion was performed. Although phlorizin normalised plasma glucose in the diabetic dog and reduced plasma glucose in normal, non-diabetic dogs, insulin dependent glucose disposition rate did not improve. While phlorizin itself was associated with insulin resistance in the normal animals, the insulin resistance of diabetes mellitus was not further augmented. We conclude that phlorizin is associated with insulin resistance perhaps by a common pathway shared by chronic hyperglycaemia. Care must be taken when phlorizin is used as an agent to stu...Continue Reading

References

Jul 1, 1979·Metabolism: Clinical and Experimental·B V HowardP H Bennett
Sep 1, 1978·The Journal of Clinical Investigation·A D CherringtonJ L Chiasson
Jan 1, 1976·The American Journal of Medicine·G M ReavenJ M Olefsky
May 1, 1987·The Journal of Clinical Investigation·L RossettiR A DeFronzo
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A StarkeR H Unger
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·V HerbertS J Bleicher
Mar 1, 1983·The Journal of Clinical Investigation·K Kawai, R H Unger
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·A L McCallR J Wurtman
Jun 1, 1980·The Journal of Clinical Investigation·O G KoltermanJ M Olefsky
Mar 1, 1981·Canadian Journal of Physiology and Pharmacology·M Silverman
Feb 1, 1982·Metabolism: Clinical and Experimental·C Gauthier, G Hetenyi
Jul 1, 1960·The Journal of Clinical Investigation·R S YALOW, S A BERSON

❮ Previous
Next ❯

Citations

Sep 1, 1995·Physiology & Behavior·S WijkstraT R Koiter
Aug 1, 1989·Diabetes Research and Clinical Practice·M KofflerP Raskin
Dec 1, 1994·The American Journal of Physiology·M B DavidsonR G Karjala

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.