Antecedents of Objectively Diagnosed Diffuse White Matter Abnormality in Very Preterm Infants.

Pediatric Neurology
Nehal A ParikhMark A Klebanoff

Abstract

Diffuse white matter abnormality (diffuse excessive high signal intensity) is the most common finding on structural brain magnetic resonance imaging (MRI) at term-equivalent age in very preterm infants. Yet, there remains a large gap in our understanding of the etiology of diffuse white matter abnormality. Our objective was to evaluate perinatal and neonatal inflammation-associated antecedents of diffuse white matter abnormality on MRI. We prospectively enrolled 110 very preterm infants born at ≤31 weeks gestational age and collected data on multiple perinatal/neonatal exposures, especially inflammation initiating-illnesses. We performed structural MRI at term-equivalent age and quantified the volume of diffuse white matter abnormality objectively. Multivariable regression was used to identify clinical antecedents of diffuse white matter abnormality. The mean (S.D.) birth gestational age of the final study sample of 98 very preterm infants was 28.3 (2.5) weeks. Multiple inflammation initiating-illnesses were associated with diffuse white matter abnormality in univariate analyses. In multivariable linear regression analyses controlling for gestational age, severe retinopathy of prematurity (P < 0.001) and bronchopulmonary dyspla...Continue Reading

Citations

Jan 11, 2021·The Journal of Pediatrics·T Michael O'SheaLex W Doyle
Dec 2, 2020·The Journal of Pediatrics·Nehal A ParikhUNKNOWN Cincinnati Infant Neurodevelopment Early Prediction Study (CINEPS) Investigators

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