PMID: 9434695Jan 22, 1998Paper

Antegrade cold blood cardioplegia is not demonstrably advantageous over cold crystalloid cardioplegia in surgery for congenital heart disease

The Journal of Thoracic and Cardiovascular Surgery
J N YoungH E Barkan

Abstract

The superiority of blood cardioplegia in pediatric cardiac surgery has not previously been challenged in a controlled clinical trial. The purpose of this study was to compare antegrade cold blood versus cold crystalloid cardioplegia in pediatric cardiac surgery. One hundred thirty-eight pediatric patients (mean age 32 months; 95% CL 24.2 to 39.8 months; range 1 day to 15 years) were prospectively randomized to receive either cold blood (4:1 dilution, blood/Plegisol, potassium chloride 15 mEq/L; n = 62) or cold crystalloid (Plegisol; n = 76) cardioplegic solution during a variety of operations for congenital heart disease. Multiple doses of cold (4 degrees C) cardioplegic solution was administered antegradely in addition to topical cooling during ischemic arrest. Myocardial recovery and outcome measures were assessed by five clinical end points: (1) inotropic support, (2) echocardiographic assessment of ventricular function, (3) overall complication rate, (4) length of stay in the intensive care unit, and (5) 30-day survival. Multiple logistic regression and multivariate analysis of variance were used to investigate which of the following clinical determinants were contributory: (1) cardioplegia, (2) urgency of operation, (3) ao...Continue Reading

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Citations

Jun 21, 2002·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Yutaka ImotoHisataka Yasui
May 9, 2003·The Annals of Thoracic Surgery·Torsten DoenstFriedhelm Beyersdorf
Jan 1, 2005·Multimedia Manual of Cardiothoracic Surgery : MMCTS·Christian Schlensak
Feb 3, 2016·Interactive Cardiovascular and Thoracic Surgery·Branko MimicMiroslav Djordjevic
Dec 23, 2015·Advanced Biomedical Research·Saeed Fazelifar, Hamid Bigdelian
Jun 27, 2006·The Annals of Thoracic Surgery·Kerstin AmarkJan Sunnegårdh
Aug 27, 2005·The Annals of Thoracic Surgery·Kerstin AmarkJan Sunnegårdh
Dec 4, 2008·The Annals of Thoracic Surgery·Pranava SinhaRichard A Jonas
Jun 30, 2004·The Journal of Thoracic and Cardiovascular Surgery·P ModiM Caputo
Jul 7, 1999·Journal of Cardiothoracic and Vascular Anesthesia·L K Davies
Jan 3, 2007·The Journal of Thoracic and Cardiovascular Surgery·Yves Durandy, Sylvie Hulin
Sep 28, 2017·Pediatric Cardiology·Konstantinos S MylonasKonstantinos P Economopoulos
Dec 26, 2018·Asian Cardiovascular & Thoracic Annals·Harvey RomoloBudi Rahmat

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