Antenatal corticosteroids and preterm offspring outcomes in hypertensive disorders of pregnancy: A Japanese cohort study.

Scientific Reports
Takafumi UshidaFumitaka Kikkawa

Abstract

To estimate whether antenatal corticosteroids (ACS) improve short- and long-term preterm offspring outcomes in singleton pregnancies complicated by hypertensive disorders of pregnancy (HDP) similar to pregnancies without HDP. This population-based retrospective study was conducted based on an analysis of data collected by the Neonatal Research Network of Japan on 21,014 singleton neonates weighing ≤1,500 g between 24 and 31 weeks' gestation during 2003-2016. Logistic regression analyses were performed to compare short- and long-term offspring outcomes between mothers receiving ACS treatment and those who did not among pregnancies with HDP and without HDP. Of 21,014 neonates, 4,806 (22.9%) were born to mothers with HDP. ACS treatment was associated with significant decreases in short-term adverse outcomes in the both HDP and non-HDP groups, with similar reduced odds of neonatal death, respiratory distress syndrome, and intraventricular haemorrhage (IVH). However, ACS treatment did not significantly decrease severe IVH (aOR 0.76; 95% CI 0.51-1.13) and periventricular leukomalacia (1.14; 0.78-1.66) in the HDP group. In addition, ACS treatment in mothers without HDP significantly decreased cerebral palsy (aOR 0.70; 95% CI 0.58-084)...Continue Reading

References

Nov 1, 1993·The Journal of Clinical Endocrinology and Metabolism·R S GolandP J Tropper
May 18, 1999·American Journal of Obstetrics and Gynecology·M M AmorimA Faúndes
Apr 5, 2005·The Medical Journal of Australia·Christine L RobertsDavid J Henderson-Smart
Apr 19, 2011·Early Human Development·Sergio FerrazzaniAlessandro Caruso
Mar 13, 2014·Pediatrics International : Official Journal of the Japan Pediatric Society·Kazuo ItabashiYoshikazu Nakamura
Jun 11, 2014·Pediatrics·Luigi GagliardiUNKNOWN Italian Neonatal Network
Apr 22, 2015·International Journal of Medical Sciences·Hiroshi IshikawaUNKNOWN Neonatal Research Network of Japan
May 21, 2015·Archives of Gynecology and Obstetrics·Ken MiyazakiMasanori Fujimura
Sep 8, 2015·Lancet·Ben W J MolG Justus Hofmeyr
Nov 11, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·S Riskin-MashiahUNKNOWN Israel Neonatal Network
Oct 26, 2016·Obstetrics and Gynecology·Nir MelamedUNKNOWN Canadian Neonatal Network Investigators
Jan 29, 2017·Acta Obstetricia Et Gynecologica Scandinavica·Everett F MagannJohn C Morrison
Mar 23, 2017·The Cochrane Database of Systematic Reviews·Devender RobertsStuart R Dalziel
May 16, 2017·JAMA Pediatrics·Mikael NormanUNKNOWN Effective Perinatal Intensive Care in Europe (EPICE) Research Group

❮ Previous
Next ❯

Methods Mentioned

BETA
SGA

Software Mentioned

SAS

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.