PMID: 7547001Aug 1, 1995Paper

Antenatal diagnosis of congenital heart disease and Down's syndrome: the potential effect on the practice of paediatric cardiology

British Heart Journal
M Abu-HarbC Wren

Abstract

To predict the effect of antenatal ultrasound screening for congenital heart disease and maternal serum screening of Down's syndrome on the practice of paediatric cardiology and paediatric cardiac surgery. A retrospective and prospective ascertainment of all congenital heart disease diagnosed in infancy in 1985-1991. One English health region. All congenital heart disease diagnosed in infancy by echocardiography, cardiac catheterisation, surgery, or necropsy was classified as "complex", "significant", or "minor" and as "detectable" or "not detectable" on a routine antenatal ultrasound scan. 1347 infants had congenital heart disease which was "complex" in 13%, "significant" in 55%, and "minor" in 32%. 15% of cases were "detectable" on routine antenatal ultrasound. Assuming 20% detection and termination of 67% of affected pregnancies, liveborn congenital heart disease would be reduced by 2%, infant mortality from congenital heart disease by 5%, and paediatric cardiac surgical activity by 3%. Maternal screening for Down's syndrome, assuming 75% uptake, 60% detection, and termination of all affected pregnancies, would reduce liveborn cases of Down's syndrome by 45%, liveborn cases of congenital heart disease by 3.5%, and cardiac su...Continue Reading

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Citations

Mar 24, 1998·Prenatal Diagnosis·U Gembruch
Jun 26, 2008·Cardiology in the Young·Monesha Gupta-MalhotraRonald Portman
Feb 4, 2003·Paediatric and Perinatal Epidemiology·Ruth BellUNKNOWN Northern Congenital Abnormality Survey Steering Group
Jan 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·J P WyllieC Wren
Jul 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·G Sharland
Jul 1, 1997·Archives of Disease in Childhood. Fetal and Neonatal Edition·M Eronen
Sep 26, 2014·World Journal of Clinical Pediatrics·Mohammed A Al-Biltagi

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