Antenatal diagnosis of isolated lissencephaly by ultrasound and magnetic resonance imaging

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
P GrecoL Selvaggi


Lissencephaly (agyria) is a cortical dysplasia associated with a disturbance in the migration of neocortical neurons. Because of abnormal sonographic findings in the brain of a 24-week fetus, we carried out serial magnetic resonance imaging (MRI) examinations which raised the suspicion of isolated lissencephaly. In the second trimester, an area of damage depicted as low-intensity signals was identified by MRI inside the cortical parenchyma. In the same cortical area, agyria was detected later in pregnancy, and postnatally calcification was observed by computerized tomography (CT) scan. We believe that ultrasound and targeted MRI examination can improve our understanding of some disorders of neuronal migration and that earlier diagnosis is feasible if both methods are employed and interpreted by sound criteria.


May 1, 2002·Prenatal Diagnosis·Gianluigi Pilu, John C Hobbins
Jul 9, 2002·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G MalingerM Glezerman
May 17, 2000·Current Opinion in Obstetrics & Gynecology·G PiluL Bovicelli
Oct 22, 2008·Obstetrical & Gynecological Survey·Lourens R PistoriusDaniela Prayer
Nov 24, 1999·Journal of Perinatal Medicine·A VimercatiL Selvaggi
May 26, 2005·Journal of Perinatal Medicine·Andrew C G BreezeEdile M Murdoch
Apr 4, 2008·La Radiologia medica·A PerroneL Manganaro
Mar 22, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Sandeep GhaiSusan Blaser
Sep 4, 2012·Seminars in Fetal & Neonatal Medicine·Ritsuko K Pooh
Aug 3, 2011·Neuroimaging Clinics of North America·Karuna Shekdar, Tamara Feygin
Mar 5, 2009·Journal of Clinical Ultrasound : JCU·Halil AslanYavuz Ceylan
Feb 25, 2009·Prenatal Diagnosis·Ants ToiSusan Blaser
Nov 23, 2010·Developmental Medicine and Child Neurology·Roobin P Jokhi, Elspeth H Whitby
Dec 27, 2005·Brain & Development·Claudio CelentanoMarco Liberati
Dec 9, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·K W FongD Chitayat
Jan 16, 2007·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G MalingerT Lerman-Sagie
May 2, 2007·Prenatal Diagnosis·Daniela PastorinoPierangela de Biasio
Jul 14, 2005·Journal of Computer Assisted Tomography·Kumaresan SandrasegaranMervyn D Cohen
Sep 28, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Tally Lerman-Sagie, Zvi Leibovitz
Jan 10, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·UNKNOWN ENSO Working Group

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