Antenatal risk factors for symptomatic congenital CMV disease following primary maternal CMV infection

Journal of Perinatal Medicine
Eran HadarJoseph Pardo

Abstract

This study aimed to evaluate antenatal risk factors associated with symptomatic congenital cytomegalovirus (CMV) disease, following in utero vertical infection. This study included a retrospective cohort of 155 neonates with congenital CMV infection, following primary maternal CMV infection during pregnancy, and were divided to symptomatic (n=95) and asymptomatic (n=60) newborns. Young maternal age (29.1±5.12 vs. 31.6±5.36 years, P=0.005), high risk occupation for viral exposure (20.0% vs. 11.7%, P=0.04), CMV IgG seroconversion at diagnosis (83.1% vs. 63.3%, P=0.005) and abnormal fetal MRI (11.6% vs. 0%, P=0.003) were found to be prognostic risk factors associated with symptomatic CMV disease of the newborn. Maternal febrile illness at diagnosis, IgG avidity, US findings and the timing of maternal infection were not associated with the occurrence of neonatal symptoms. Knowledge of the reported risk factors may assist in counseling parents with intra uterine CMV infection.

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Citations

Apr 20, 2016·Journal of Perinatal Medicine·Wayne R Cohen
Oct 10, 2020·PloS One·Gail J Demmler-HarrisonUNKNOWN Houston Congenital Cytomegalovirus Longitudinal Study Group
Nov 3, 2021·BMC Pregnancy and Childbirth·Rita ZlatkinAnat Shmueli

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Methods Mentioned

BETA
SGA
PCR

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Statistical Package for Social Science ( SPSS

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