Antepartum intravenous immunoglobulin therapy in refractory pemphigoid gestationis: case report and literature review

Journal of Cutaneous Medicine and Surgery
Philip Doiron, Melanie Pratt

Abstract

pemphigoid gestationis is an autoimmune blistering disease affecting pregnant women. Treatment often consists of topical corticosteroids, oral antihistamines, and oral prednisone followed by immunosuppressants. Refractory cases in antepartum patients present a particular therapeutic challenge as the majority of second-line agents are contraindicated until the patient has delivered. the following report describes the case of a 34-year-old woman pregnant for the third time at 16 weeks' gestation. Her previous two pregnancies were complicated by pemphigoid gestationis but were successfully managed with oral prednisone and topical agents. During her third pregnancy, the initial lesions were controlled with oral prednisone, but attempts to decrease her dose resulted in disease flare. monthly infusions of intravenous immunoglobulin (40 g intravenously for 3 consecutive days for 120 g total) proved to be successful in reducing the dose of oral prednisone required to maintain disease remission. A healthy baby was delivered at 37.5 weeks.

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Citations

Sep 3, 2014·Orphanet Journal of Rare Diseases·Laura HuilajaKaisa Tasanen
May 3, 2011·Actas dermo-sifiliográficas·R Ruiz-VillaverdeC L Ramirez-Tortosa
Sep 20, 2011·Dermatologic Clinics·Lizbeth R A Intong, Dédée F Murrell
Oct 20, 2011·Clinical and Experimental Dermatology·M P Beard, G W M Millington
Aug 7, 2013·Dermatologic Therapy·Stephanie Lehrhoff, Miriam Keltz Pomeranz
Mar 15, 2015·International Immunopharmacology·Tegan NguyenA Razzaque Ahmed
Dec 7, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·M De la CalleJ L Bartha
Apr 9, 2018·BMJ Case Reports·Filipa Tavares AlmeidaCeleste Brito
Aug 6, 2017·Clinical Reviews in Allergy & Immunology·Kyle T AmberLuca Borradori

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