Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response

Nature Communications
Jinho JhangJin-Hee Han

Abstract

Prefrontal brain areas are implicated in the control of fear behavior. However, how prefrontal circuits control fear response to innate threat is poorly understood. Here, we show that the anterior cingulate cortex (ACC) and its input to the basolateral nucleus of amygdala (BLA) contribute to innate fear response to a predator odor in mice. Optogenetic inactivation of the ACC enhances freezing response to fox urine without affecting conditioned freezing. Conversely, ACC stimulation robustly inhibits both innate and conditioned freezing. Circuit tracing and slice patch recordings demonstrate a monosynaptic glutamatergic connectivity of ACC-BLA but no or very sparse ACC input to the central amygdala. Finally, our optogenetic manipulations of the ACC-BLA projection suggest its inhibitory control of innate freezing response to predator odors. Together, our results reveal the role of the ACC and its projection to BLA in innate fear response to olfactory threat stimulus.

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Citations

Jul 7, 2020·Experimental Neurobiology·Jun-Young OhHyungju Park
Aug 22, 2020·Psychopharmacology·Daniel LustbergDavid Weinshenker
Mar 8, 2019·Frontiers in Behavioral Neuroscience·Rupshi Mitra
Aug 20, 2019·Journal of Neuroscience Research·Kesong Hu
Jul 1, 2020·Behavioural Brain Research·Atsuhito YamagishiNobuya Sato
Mar 27, 2020·Trends in Neurosciences·Sahana Murthy, Elizabeth Gould
May 1, 2020·Trends in Neurosciences·Sabrina van HeukelumMartha N Havenith
Apr 5, 2021·Frontiers in Psychology·Ibuki KoanShin Nakagawa
Apr 16, 2021·Current Biology : CB·Sabrina van HeukelumArthur S C França

Methods Mentioned

BETA
transgenic
transfection
PCR

Related Concepts

Metazoa
Behavior, Animal
Conditioned Reflex
Implantable Stimulation Electrodes
Electroconvulsive Shock
Fear (Mental Process)
Genus Urocyon
Cingulate Cortex
Mice, Inbred C57BL
Founder Mice, Transgenic

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