Anterior cingulate cortex is necessary for adaptation of action plans

Proceedings of the National Academy of Sciences of the United States of America
Adam T BrockettMatthew R Roesch

Abstract

Previous research has focused on the anterior cingulate cortex (ACC) as a key brain region in the mitigation of the competition that arises from two simultaneously active signals. However, to date, no study has demonstrated that ACC is necessary for this form of behavioral flexibility, nor have any studies shown that ACC acts by modulating downstream brain regions such as the dorsal medial striatum (DMS) that encode action plans necessary for task completion. Here, we performed unilateral excitotoxic lesions of ACC while recording downstream from the ipsilateral hemisphere of DMS in rats, performing a variant of the STOP-signal task. We show that on STOP trials lesioned rats perform worse, in part due to the failure of timely directional action plans to emerge in the DMS, as well as the overrepresentation of the to-be-inhibited behavior. Collectively, our findings suggest that ACC is necessary for the mitigation of competing inputs and validates many of the existing theoretical predictions for the role of ACC in cognitive control.

References

Jan 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J V PardoM E Raichle
Aug 8, 2001·Psychological Review·M M BotvinickJ D Cohen
Jun 25, 2002·Trends in Neurosciences·Verity J Brown, Eric M Bowman
Feb 12, 2005·Brain : a Journal of Neurology·Lesley K Fellows, Martha J Farah
Jun 20, 2006·Nature Neuroscience·Steven W KennerleyMatthew F S Rushworth
Jan 15, 2008·Cognitive, Affective & Behavioral Neuroscience·Mattew M Botvinick
Sep 19, 2008·Trends in Cognitive Sciences·Frederick Verbruggen, Gordon D Logan
Oct 7, 2008·Trends in Neurosciences·Steven P Wise
Sep 20, 2011·Nature Neuroscience·William H Alexander, Joshua W Brown
Jan 10, 2012·Trends in Cognitive Sciences·Clay B Holroyd, Nick Yeung
Feb 24, 2012·The European Journal of Neuroscience·Vadim KashtelyanMatthew R Roesch
Apr 12, 2012·Science·Nils KollingMatthew F S Rushworth
Sep 14, 2012·Frontiers in Integrative Neuroscience·Daniel W BrydenMatthew R Roesch
Jul 30, 2014·Nature Neuroscience·Amitai ShenhavMatthew M Botvinick
Aug 1, 2014·Cognitive Science·Matthew M Botvinick, Jonathan D Cohen
Dec 2, 2014·Psychological Review·Clay B Holroyd, Samuel M McClure
Mar 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel W Bryden, Matthew R Roesch
Jul 21, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel W BrydenMatthew R Roesch
Jan 18, 2016·Current Opinion in Neurobiology·N KollingMfs Rushworth
Jul 28, 2016·Biological Psychiatry·Sarah R HeilbronnerSuzanne N Haber
Sep 28, 2016·Nature Neuroscience·R Becket Ebitz, Benjamin Yost Hayden
Sep 28, 2016·Nature Neuroscience·Nils KollingMatthew F S Rushworth
Sep 28, 2016·Nature Neuroscience·Amitai ShenhavMatthew M Botvinick
Jun 22, 2017·Frontiers in Neuroscience·Eliana VassenaWilliam H Alexander
Jan 24, 2018·The European Journal of Neuroscience·Kyuhyun ChoiMarc V Fuccillo
Nov 9, 2018·ENeuro·Mark LaubachSamantha R White
Apr 17, 2019·Nature Neuroscience·Elsa F FouragnanMatthew F S Rushworth
Jul 8, 2019·Trends in Cognitive Sciences·Avinash R VaidyaLesley K Fellows
Oct 28, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mieke van Holstein, Stan B Floresco
Dec 6, 2019·The European Journal of Neuroscience·Pragathi Priyadharsini BalasubramaniBenjamin Y Hayden

❮ Previous
Next ❯

Software Mentioned

Neuroexplorer
Offline Sorter
Matlab

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Tor D WagerTal Yarkoni
Der Internist
R Wronski, W E Schmidt
Current Oncology Reports
Sina Jasim, Mouhammed Amir Habra
International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology
Christoph MulertGeorg Winterer
© 2021 Meta ULC. All rights reserved