Anterior cruciate ligament reconstruction in a rabbit model using canine small intestinal submucosa and autologous platelet-rich plasma

The Journal of Surgical Research
A-Jin LeeHwi-Yool Kim

Abstract

The bone-ligament interface is the main point of failure after anterior cruciate ligament reconstruction. Synthetic ligament materials have problems such as a greater failure rate of the bone-ligament insertion than autografts. Small intestinal submucosa (SIS) is a biologic scaffold that has been used to repair musculoskeletal tissue and has been shown to promote cell migration and enhance collagen fiber regeneration. Autologous platelet-rich plasma (PRP) has also been investigated as a potential promoter of tendon healing. We investigated SIS and PRP as biomaterials that might strengthen the bone-tunnel interface and improve tendon structure formation. Anterior cruciate ligament grafts were formed of braid-twist canine SIS. These canine SIS ligament grafts were used for anterior cruciate ligament reconstruction in 20 New Zealand white rabbits. The rabbits were divided into 2 treatment groups. In 1 group (SIS group; n = 10), we only implanted the canine SIS grafts. In the second group (PRP group; n = 10), we applied autologous PRP to the surgical area after implantation of canine SIS grafts. We determined the cytokine level of the autologous PRP using a transforming growth factor-β1 enzyme-linked immunosorbent assay kit. At 1 a...Continue Reading

References

Jul 1, 1989·The Journal of Surgical Research·S F BadylakL A Geddes
Sep 27, 2003·Tissue Engineering·James Cho-Hong GohEng-Hin Lee
Dec 6, 2003·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Volker MusahlSavio L-Y Woo
Jul 28, 2005·Biomaterials·Cato T Laurencin, Joseph W Freeman
Aug 2, 2005·International Journal of Oral and Maxillofacial Surgery·B-H ChoiJ-H Jung
Aug 17, 2005·Injury·Rozalia DimitriouPeter V Giannoudis
Mar 4, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rui LiangSteven D Abramowitch
Mar 24, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martha M MurrayDavid Zurakowski
Apr 4, 2006·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Frank A PetriglianoBenjamin M Wu
Nov 14, 2006·Journal of Biomechanics·Joseph W FreemanCato T Laurencin
Sep 22, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Wei WuTianqiu Mao
Mar 4, 2008·The Journal of Bone and Joint Surgery. American Volume·Peyton L HaysScott A Rodeo

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Citations

Jan 21, 2016·Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T·Juan C GonzálezJorge U Carmona
Dec 4, 2014·Research in Veterinary Science·Ji-Young NaJungkee Kwon
Nov 11, 2017·Orthopaedic Journal of Sports Medicine·Adam T HexterGordon Blunn
May 1, 2019·Tissue Engineering. Part B, Reviews·Isabel CalejoManuela E Gomes
Mar 1, 2014·Orthopaedic Journal of Sports Medicine·Sai-Chuen FuKai-Ming Chan
Aug 23, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Guangxiu CaoXiaoming Li
May 10, 2017·Journal of Applied Biomaterials & Functional Materials·Santiago de la Garza-CastroOscar F Mendoza-Lemus

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