Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models.

Journal of Immunological Methods
T GrayTed R Hupp

Abstract

The Anterior Gradient (AGR) genes AGR2 and AGR3 are part of the Protein Disulfide Isomerase (PDI) family and harbour core thioredoxin folds (CxxS motifs) that have the potential to regulate protein folding and maturation. A number of proteomics and transcriptomics screens in the fields of limb regeneration, cancer cell metastasis, pro-oncogenic oestrogen-signalling, and p53 regulation have identified AGR2 as a novel component of these signalling pathways. Curiously, despite the fact that the AGR2 and AGR3 genes are contiguous on chromosome 7p21.1-3, the AGR3 protein has rarely been identified in such OMICs screens along with AGR2 protein. Therefore there is little information on how AGR3 protein is expressed in normal and diseased states. A panel of three monoclonal antibodies was generated towards AGR3 protein for identifying novel clinical models that can be used to define whether AGR3 protein could play a positive or negative role in human cancer development. One monoclonal antibody was AGR3-specific and bound a linear epitope that could be defined using both pep-scan and phage-peptide library screening. Using this monoclonal antibody, endogenous AGR3 protein expression was shown to be cytosolic in four human ovarian cancer ...Continue Reading

References

Oct 19, 2001·European Journal of Biochemistry·A Yagui-BeltranT R Hupp
Mar 26, 2003·The American Journal of Pathology·Christine A Iacobuzio-DonahueMichael Goggins
May 23, 2003·The Journal of Biological Chemistry·Heli I AlanenLloyd W Ruddock
Feb 18, 2004·Molecular & Cellular Proteomics : MCP·Elizabeth PohlerTed R Hupp
Aug 12, 2004·International Journal of Cancer. Journal International Du Cancer·Edoardo MissiagliaNicholas R Lemoine
Apr 19, 2005·Genes, Chromosomes & Cancer·Jin-San ZhangCharles Y F Young
Jun 17, 2005·Cancer Research·Denis A SmirnovS Mark O'Hara
Aug 3, 2005·Cancer Research·Kenneth MacleodSimon P Langdon
Mar 29, 2007·PloS One·Anson W LowePatrick O Brown
Jun 9, 2007·Breast Cancer Research : BCR·Alan MackayMitch Dowsett
Dec 19, 2007·The Journal of Cell Biology·Irina RaykhelLloyd Ruddock
Dec 21, 2007·Biochimica Et Biophysica Acta·Christian Appenzeller-Herzog, Lars Ellgaard
Mar 31, 2009·Molecular & Cellular Proteomics : MCP·Arzu UmarLjiljana Pasa-Tolić
Apr 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sung-Woo ParkDavid J Erle
May 23, 2009·Nature Reviews. Cancer·Robert C BastGordon B Mills
May 30, 2009·Antioxidants & Redox Signaling·Feras Hatahet, Lloyd W Ruddock
Oct 17, 2009·The American Journal of Pathology·Dong L BarracloughPhilip S Rudland
Feb 2, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Sébastien LepreuxEric Chevet
Apr 1, 2011·The American Journal of Surgical Pathology·Erin R KingKwong-Kwok Wong

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Citations

Feb 5, 2014·Biochemistry. Biokhimii︠a︡·S S ShishkinM A Kovaleva
Apr 22, 2014·Experimental and Molecular Pathology·Veronika BrychtovaBorivoj Vojtesek
Sep 23, 2014·Genetics Research International·Eugenia PoliakovIgor B Rogozin
Feb 16, 2013·Scientific Reports·Anastasiya S IvanovaAndrey G Zaraisky
May 6, 2015·Seminars in Cancer Biology·Veronika BrychtovaTed R Hupp
Feb 11, 2015·European Journal of Cell Biology·Joanna ObaczRoman Hrstka
Jan 30, 2015·Scientific Reports·Anastasiya S IvanovaAndrey G Zaraisky
Jul 16, 2017·Gene Expression Patterns : GEP·Li LiZhongjie Chang
Jul 4, 2018·Acta Crystallographica. Section F, Structural Biology Communications·Van Dat NguyenLloyd W Ruddock
Sep 22, 2018·Biology of the Cell·Frederic DelomDelphine Fessart
Jul 4, 2012·Virchows Archiv : an International Journal of Pathology·S Darb-EsfahaniC Denkert
Jul 12, 2019·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Qiao XuYongjie Ma
Aug 25, 2018·Oncotarget·Areege KamalDharani K Hapangama
Feb 9, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Emmanuel Agosto-ArroyoShuko Harada
Oct 16, 2019·Oncology Letters·Joanna ObaczDelphine Fessart
Aug 29, 2021·Journal of Experimental & Clinical Cancer Research : CR·Delphine FessartGuillaume Babin
Sep 1, 2021·Clinical Breast Cancer·Carolina Leão de MoraesWaldemar Naves do Amaral

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