PMID: 1206426Dec 1, 1975Paper

Anterior horn cell disease seen in South India

Journal of the Neurological Sciences
Z A SayeedK Valmikinathan

Abstract

Thirty-two patients with clinical evidence of anterior horn cell dysfunction are descirbed. This group of patients could be divided into those with bulbar dysfunction, and those without. Eighth cranial nerve involvement was seen in 10%. The commonest perpheral distribution seen was symmetrical involvement of all four extremities. During the period of follow-up (1 to 5 years) none of the patients without bulbar dysfunction initially developed such symptoms. In all these patients electromyographic evidence of anterior horn cell disease was confirmed. The motor nerve conduction velocities in all of these patients were normal. None of them showed signs of pyramidal tract involvement. Muscle biopsy showed evidence of group fibre atrophy in 10 cases, was normal in 3, and showed a myopathic pattern in 1. Sural nerve biopsy obtained in a single patient was considered histologically normal. Plasma citrate and plasma pyruvate levels obtained in 5 patients of this group, showed elevated values for plasma citrate with normal plasma pyruvate levels. Conspicuous absence of pyramidal signs, elevated plasma citrate, normal plasma pyruvate values and the extremely slow progression suggest that this group of patients are different from other var...Continue Reading

References

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Citations

Sep 1, 1976·Journal of the Neurological Sciences·Z A SayeedK Valmikinathan
May 1, 1981·Journal of the Neurological Sciences·V GallaiG Rushworth
Sep 1, 1994·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·R J Davenport, C J Mumford
Apr 9, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·J VelmuruganP Satishchandra
Aug 1, 1991·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J M AbarbanelK R Chapman

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