Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS

Journal of the Neurological Sciences
Yukio FujitaKoichi Okamoto

Abstract

Recently, TAR DNA-binding protein of 43-kDa (TDP-43) was identified as a major component of ubiquitinated neuronal cytoplasmic inclusions observed in lower motor neurons in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions. We herein investigated the relationship between TDP-43 immunoreactivities and fragmentation of the Golgi apparatus (GA). Each mirror section of spinal cord tissues in 10 ALS and 3 control cases were immunostained with polyclonal anti-TDP-43 and polyclonal anti-trans-Golgi-network (TGN)-46 antibodies. The neurons were divided into subtypes according to differences in TDP-43 immunoreactivities, and we examined the morphological changes of GA in each type. We divided the neurons into four subtypes according to the observed differences in TDP-43 immunoreactivities, Type A: neurons showing normal nuclear staining, Type B: neurons showing a loss of normal nuclear staining and a few granular cytoplasmic immunoreactivities, Type C: neurons showing a lot of granular immunoreactivities and no inclusions, Type D: neurons with inclusions. All of the neurons in Type A showed normal GA profiles, however, almost all of the neurons with abnormal TDP-43 immunoreactivities...Continue Reading

References

Mar 6, 1992·Cell·I Mellman, K Simons
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·Z MourelatosN K Gonatas
Jul 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S CroulN K Gonatas
Jul 15, 1987·The Journal of Comparative Neurology·C H RhodesN K Gonatas
Jan 1, 1985·Annual Review of Cell Biology·M G Farquhar
Jun 1, 1993·Annals of Neurology·Z MourelatosN K Gonatas
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z MourelatosM C Dal Canto
Oct 4, 2002·Proceedings of the National Academy of Sciences of the United States of America·I-Fan WangC-K James Shen
Dec 31, 2005·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yukio Fujita, Koichi Okamoto
Mar 21, 2006·Journal of the Neurological Sciences·Nicholas K GonatasJacqueline O Gonatas
Mar 16, 2007·Journal of Neuropathology and Experimental Neurology·Manuela NeumannVirginia M-Y Lee

❮ Previous
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Citations

Jun 7, 2011·Acta Neuropathologica·Hidefumi ItoHideshi Kawakami
Apr 8, 2009·Current Neurology and Neuroscience Reports·Paul N ValdmanisGuy A Rouleau
Dec 1, 2011·Nature Reviews. Neuroscience·Edward B LeeJohn Q Trojanowski
Jun 22, 2010·Antioxidants & Redox Signaling·Melissa NassifClaudio Hetz
Apr 20, 2010·Human Molecular Genetics·Clotilde Lagier-TourenneDon W Cleveland
Jan 28, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Koichi OkamotoYuji Mizuno
May 26, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yukio FujitaKoichi Okamoto
Jul 30, 2010·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Yukio FujitaKoichi Okamoto
Jun 23, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Koichi OkamotoMasamitsu Takatama
Feb 20, 2009·Journal of Neuropathology and Experimental Neurology·Montse OlivéIsidre Ferrer
Apr 22, 2009·Neuroscience Letters·Xiaoyang ShanCharles Krieger
Jul 29, 2008·Neuropathology and Applied Neurobiology·A M IsaacsS Brandner
Sep 14, 2012·Journal of Neurochemistry·Jianbin TongHongxia Zhou
Jan 17, 2013·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Natsumi FurutaKoichi Okamoto
Apr 3, 2009·Brain Pathology·Maria Teresa GiordanaMaria Teresa Rinaudo
Apr 23, 2015·Neurotoxicology·Emma Muñoz-SáezBegoña Gómez Miguel
Feb 2, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Janin LautenschlaegerJulian Grosskreutz
Nov 21, 2018·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Feb 6, 2019·Acta Neuropathologica·Katja Burk, R Jeroen Pasterkamp
Feb 12, 2019·Critical Reviews in Biochemistry and Molecular Biology·S ParakhJ D Atkin
Nov 19, 2015·Frontiers in Neuroscience·Vinod SundaramoorthyJulie D Atkin
Mar 7, 2020·Journal of Neuropathology and Experimental Neurology·Kensuke IkenakaGen Sobue
May 24, 2020·International Journal of Molecular Sciences·Stefan BräuerAndreas Hermann
Dec 5, 2018·Acta Neuropathologica·Alissa L NanaWilliam W Seeley
Dec 24, 2019·Frontiers in Neuroscience·Rita MejziniP Anthony Akkari
Nov 29, 2011·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Koichi Okamoto
Nov 6, 2015·Frontiers in Neuroscience·Thomas Schmitt-John
May 26, 2017·Frontiers in Molecular Neuroscience·Hamideh ShahheydariJulie D Atkin
Jul 25, 2019·Cells·José Ángel Martínez-MenárguezEmma Martínez-Alonso
Jan 10, 2021·Journal of Neuropathology and Experimental Neurology·Isidro FerrerMónica Povedano

❮ Previous
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