PMID: 6329458Jun 8, 1984Paper

Anterior hypothalamic lesions prevent the endotoxin-induced reduction of beta-adrenoceptor number in guinea pig lung

Brain Research
A J Van Oosterhout, F P Nijkamp


Bacterial endotoxin (E. coli O111:B4) induces, 4 days after intraperitoneal injection, a 30% reduction of guinea pig lung beta-adrenoceptor number (Bmax). No change in affinity (Kd) for the receptors occurred. Bilateral electrolytic lesions centered in the anterior hypothalamic nucleus prevent this reduction in Bmax and even reverse the reduction into a small increase in beta-adrenoceptor number. Since it is known from the literature data that anterior hypothalamic lesions as well as beta-adrenoceptor stimulants have an inhibitory influence on the immune system, the mechanism by which these lesions inhibit the reduction of beta-adrenoceptor sites after bacterial endotoxin and influence immune functions, may be related.


Nov 1, 1975·The Journal of Allergy and Clinical Immunology·J A KramK L Melmon
Nov 5, 1977·British Medical Journal
Jan 1, 1973·International Archives of Allergy and Applied Immunology·W Schmutzler, R Derwall
Dec 1, 1973·The Journal of Allergy and Clinical Immunology·R H ShereffH Robinson
Nov 1, 1967·Journal of Psychosomatic Research·T J Luparello
Jan 28, 1983·European Journal of Pharmacology·A J SchreursF P Nijkamp

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