Anterior Insula Regulates Multiscale Temporal Organization of Sleep and Wake Activity

Journal of Biological Rhythms
Michael C ChenJun Lu

Abstract

The role of specific cortical regions in sleep-regulating circuits is unclear. The anterior insula (AI) has strong reciprocal connectivity with wake and sleep-promoting hypothalamic and brainstem regions, and we hypothesized that the AI regulates patterns of sleep and wakefulness. To test this hypothesis, we lesioned the AI in rats (n = 8) and compared sleep, wake, and activity regulation in these animals with nonlesioned controls (n = 8) with 24-h sleep recordings and chronic infrared activity monitoring. Compared to controls, animals with AI lesions had decreased wakefulness and increased rapid eye movement (REM) sleep and non-REM (NREM) sleep. AI-lesioned animals had shorter wake bouts, especially during the active dark phase. AI-lesioned animals also had more transitions from NREM to REM sleep, especially during the inactive light phase. Chronic infrared monitoring revealed that AI-lesioned animals also had a disturbed temporal organization of locomotor activity at multiple time scales with more random activity fluctuations from 4 to 12 h despite intact circadian rhythms. These results suggest that the AI regulates sleep and activity and contributes to the regulation of sleep and motor behavior rhythmicity across multiple t...Continue Reading

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Citations

Oct 30, 2019·Journal of Cognitive Neuroscience·Zhuo FangStuart M Fogel
Mar 3, 2020·Frontiers in Computational Neuroscience·Michael C ChenJun Lu
May 10, 2020·Cerebral Cortex·Fillan GradyJoel C Geerling
Aug 14, 2020·Physiological Reviews·Eus J W Van Someren
Jul 14, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Santiago AlcaidePablo Barttfeld
Aug 11, 2021·Neuroscience and Biobehavioral Reviews·Jacob R BumgarnerRandy J Nelson

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