Anterior insular cortex is a bottleneck of cognitive control

NeuroImage
Tingting WuJin Fan

Abstract

Cognitive control, with a limited capacity, is a core process in human cognition for the coordination of thoughts and actions. Although the regions involved in cognitive control have been identified as the cognitive control network (CCN), it is still unclear whether a specific region of the CCN serves as a bottleneck limiting the capacity of cognitive control (CCC). Here, we used a perceptual decision-making task with conditions of high cognitive load to challenge the CCN and to assess the CCC in a functional magnetic resonance imaging study. We found that the activation of the right anterior insular cortex (AIC) of the CCN increased monotonically as a function of cognitive load, reached its plateau early, and showed a significant correlation to the CCC. In a subsequent study of patients with unilateral lesions of the AIC, we found that lesions of the AIC were associated with a significant impairment of the CCC. Simulated lesions of the AIC resulted in a reduction of the global efficiency of the CCN in a network analysis. These findings suggest that the AIC, as a critical hub in the CCN, is a bottleneck of cognitive control.

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Citations

Nov 2, 2019·The Journal of Comparative Neurology·Tingting WuJin Fan
Jul 30, 2019·Journal of Alzheimer's Disease : JAD·Hao HeYuejia Luo
Feb 9, 2021·Frontiers in Human Neuroscience·John R Kershner
Mar 11, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Rune BoenChristian K Tamnes
Mar 29, 2021·Cerebral Cortex·Daniel BrennanJin Fan
Apr 4, 2021·Journal of Clinical Medicine·Francesco LatiniMats Ryttlefors
Nov 7, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Alfredo SpagnaJin Fan
Jun 3, 2021·Biomolecules·Goran ŠimićPatrick R Hof
Aug 20, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vinod Menon, Mark D'Esposito
Aug 31, 2021·Neuropharmacology·Samuel W CentanniFrederic W Hopf

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