Anterior pituitary dysfunction following traumatic brain injury (TBI)

Clinical Endocrinology
Amar Agha, Christopher J Thompson

Abstract

Traumatic brain injury (TBI) is the commonest cause of death and disability in young adults living in industrialized countries. Several recent studies have convincingly shown that anterior hypopituitarism is a common complication of head trauma with a prevalence of at least 25% among long-term survivors. This is a much higher frequency than previously thought and suggests that most cases of post-traumatic hypopituitarism (PTHP) remain undiagnosed and untreated. These findings raise important questions about the potential contribution of PTHP to the high physical and neuropsychiatric morbidity seen in this group of patients. In this review, we examine the published reports on the neuroendocrine abnormalities in TBI patients and highlight new data that give novel insights into the natural history of this disorder. We discuss the potential contribution of PTHP to recovery and rehabilitation after injury and the need for the identification and the appropriate and timely management of hormone deficiencies to optimize patient recovery from head trauma, improve quality of life and avoid the long-term adverse consequences of untreated hypopituitarism.

References

Oct 1, 1977·The Journal of Clinical Endocrinology and Metabolism·D RudmanJ F Raggio
Nov 1, 1978·Journal of Neurosurgery·A S FleischerG T Tindall
May 1, 1992·The American Journal of Clinical Nutrition·A BinnertsS W Lamberts
Feb 1, 1991·Journal of Applied Physiology·R C CuneoP H Sönksen
Jan 1, 1989·Acta Paediatrica Scandinavica. Supplement·S BjörkJ E Levin
Apr 1, 1986·European Journal of Pediatrics·U EiholzerA Prader
Sep 1, 1988·The Journal of Trauma·R ChioléroE Jéquier
Mar 13, 1986·The New England Journal of Medicine·P DandonaD M Flynn
Jul 13, 1974·Lancet·G Teasdale, B Jennett
Jan 1, 1971·Brain : a Journal of Neurology·M R Crompton
Sep 1, 1981·Neurosurgery·L R KingV K Piziak
Aug 1, 1994·Brain Injury : [BI]·S C LeeJ S Kreutzer
May 1, 1996·Journal of Endocrinological Investigation·P IglesiasJ J Diez
Jul 1, 1997·Social Science & Medicine·K McGregor, B Pentland
Mar 10, 1998·Journal of Endocrinological Investigation·S BenvengaF Trimarchi
Jan 12, 1999·Disability and Rehabilitation·J M Mazaux, E Richer
Jan 14, 1999·The Journal of Head Trauma Rehabilitation·R L DelmonicoJ Englander
Jan 30, 1999·International Journal of Rehabilitation Research. Internationale Zeitschrift Für Rehabilitationsforschung. Revue Internationale De Recherches De Réadaptation·P TargetS Gorton
Jan 11, 2000·Brain Injury : [BI]·I CernakS Markovic
Jun 13, 2003·Endocrinology and Metabolism Clinics of North America·Greet Van den Berghe
Feb 21, 2004·Clinical Endocrinology·Catherine A LissettUNKNOWN KIMS International Board
Apr 24, 2004·Clinical Endocrinology·Amar AghaChristopher J Thompson
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Brent E Masel
Jul 16, 2004·Journal of Neurotrauma·Marta BondanelliEttore C I degli Uberti
Oct 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Amar AghaChristopher J Thompson
Dec 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Amar AghaChristopher J Thompson
Mar 11, 2005·European Journal of Endocrinology·Amar AghaChristopher J Thompson
Apr 15, 2005·American Journal of Physical Medicine & Rehabilitation·Amar AghaChristopher J Thompson
May 18, 2005·QJM : Monthly Journal of the Association of Physicians·A AghaC J Thompson
Sep 8, 2005·The Journal of Clinical Endocrinology and Metabolism·Gianluca AimarettiEzio Ghigo
Dec 28, 2005·The American Journal of Medicine·Amar AghaChristopher J Thompson

❮ Previous
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Citations

Nov 30, 2007·Intensive Care Medicine·Balachandra MaiyaDavid Menon
Jun 8, 2010·Pituitary·Valentina GascoGianluca Aimaretti
May 28, 2010·Journal of Neurotrauma·Brent E Masel, Douglas S DeWitt
Jun 5, 2012·Journal of Neurotrauma·Brent E MaselDouglas S DeWitt
Jul 17, 2007·Current Opinion in Pediatrics·Silvia Einaudi, Claudia Bondone
Nov 3, 2011·Neurosurgical Focus·Julie Dubourg, Mahmoud Messerer
Dec 11, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Halil UlutabancaFahrettin Kelestimur
May 11, 2013·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·F ProdamG Aimaretti
Sep 4, 2014·Journal of Medical Case Reports·Alejandro Cob
Jan 18, 2007·European Journal of Pediatrics·Preamrudee Poomthavorn, Margaret Zacharin
Aug 5, 2015·Journal of Clinical Medicine·Cristina CapatinaNiki Karavitaki
Aug 5, 2015·Journal of Clinical Medicine·Christine Streetz-van der WerfIlonka Kreitschmann-Andermahr
Feb 26, 2014·Brain Injury : [BI]·Dennis J ZgaljardicMelinda Sheffield-Moore
Jun 20, 2007·Brain Injury : [BI]·Fateme SalehiMichael Cusimano
Nov 10, 2012·The American Journal of the Medical Sciences·Michael T Flannery, Robert C Flannery
Jun 2, 2012·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Gabriel Obiols Alfonso
Sep 21, 2010·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Joana MesquitaJosé Luís Medina
Aug 28, 2010·The Journal of Pediatrics·Anne-Marie D KaulfersSusan R Rose
Dec 23, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Dorothee WachterDieter-Karsten Böker
Jan 30, 2008·Endocrinology and Metabolism Clinics of North America·Andrew A Toogood, Paul M Stewart
Oct 18, 2014·Journal of Neurotrauma·Brent E Masel, Randy Urban
Sep 7, 2007·Clinical Endocrinology·M SchneiderG K Stalla
Apr 9, 2010·Acta Clinica Belgica·O AlexopoulouD Maiter
May 26, 2007·Clinical Endocrinology·M KloseU Feldt-Rasmussen
Jul 30, 2014·Developmental Neurobiology·Tiffany GrecoMayumi L Prins
Jul 15, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nicholas A TritosUNKNOWN AACE Neuroendocrine and Pituitary Scientific Committee
Mar 19, 2008·The Journal of Pediatrics·Anna McDonaldCarlo L Acerini
Sep 28, 2016·Journal of Endocrinological Investigation·A TölliC Höybye
Mar 2, 2017·International Journal of Environmental Research and Public Health·Shih-Wei LiuSu-Shun Lo
Nov 23, 2016·Archives of Disease in Childhood·Paula Casano-Sancho
Nov 14, 2013·The Journal of Head Trauma Rehabilitation·Kathryn WunderleJeffrey J Bazarian
Oct 30, 2010·The American Journal of Forensic Medicine and Pathology·Kazuhiko KibayashiAyako Ro
Oct 25, 2006·Mental Retardation and Developmental Disabilities Research Reviews·F Daniel Armstrong
Mar 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Gianluca Aimaretti, Ezio Ghigo

❮ Previous
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