Anterior pituitary thyrotropes are multifunctional cells

American Journal of Physiology. Endocrinology and Metabolism
Carlos VillalobosJ García-Sancho

Abstract

Anterior pituitary (AP) contains some unorthodox multifunctional cells that store and secrete two different AP hormones (polyhormonal cells) and/or respond to several hypothalamic-releasing hormones (HRHs; multiresponsive cells). Multifunctional cells may be involved in paradoxical secretion (secretion of a given AP hormone evoked by a noncorresponding HRH) and transdifferentiation (phenotypic switch between different mature cell types without cell division). Here we combine calcium imaging (to assess responses to the four HRHs) and multiple sequential immunoassay of the six AP hormones to perform a single-cell phenotypic study of thyrotropes in normal male and female mice. Surprisingly, most of the thyrotropes were polyhormonal, containing, in addition to thyrotropin (TSH), luteinizing hormone (40-42%) and prolactin (19-21%). Thyrotropes costoring growth hormone and/or ACTH were found only in females (24% of each type). These results suggest that costorage of the different hormones does not happen at random and that gender favors certain hormone combinations. Our results indicate that thyrotropes are a mosaic of cell phenotypes rather than a single cell type. The striking promiscuity of TSH storage should originate considerabl...Continue Reading

References

Feb 1, 1977·The Journal of Clinical Endocrinology and Metabolism·S MatsukuraM Fukase
Nov 1, 1991·Endocrine Reviews·L S Frawley, F R Boockfor
Jun 1, 1990·The Journal of Endocrinology·S Harvey
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·A LuiniJ Axelrod
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G A ShangoldR J Miller
Mar 30, 1994·Biochemical and Biophysical Research Communications·K KasaharaO Tanizawa
Apr 1, 1996·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C VillalobosJ Garcia-Sancho
Jan 1, 1997·Hormone Research·A BarlierA Enjalbert
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·C VillalobosA Sánchez
Feb 9, 2000·Virchows Archiv : an International Journal of Pathology·S VidalB W Scheithauer
Jun 17, 2000·Trends in Endocrinology and Metabolism : TEM·G V Childs
Feb 24, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S VidalH S Smyth
Apr 6, 2002·Archives of Physiology and Biochemistry·E SeuntjensC Denef
Apr 6, 2002·Archives of Physiology and Biochemistry·G V Childs
May 6, 2003·The Journal of Physiology·Lucía NuñezJavier García-Sancho
May 1, 1991·Trends in Endocrinology and Metabolism : TEM·G V Childs

❮ Previous
Next ❯

Citations

Nov 15, 2008·The Journal of Endocrinology·Audrey F SeasholtzRobert C Thompson
Feb 14, 2016·General and Comparative Endocrinology·Yugo WatanabeBert De Groef
Sep 20, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A AndersonL S Kean
Apr 8, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Lacey LutzDonal C Skinner
Apr 20, 2006·The International Journal of Biochemistry & Cell Biology·Chung-Man YeungChristopher H K Cheng
Sep 18, 2012·Frontiers in Neuroendocrinology·P R Le TissierP Mollard
Dec 4, 2019·General and Comparative Endocrinology·Romain FontaineFinn-Arne Weltzien
Mar 8, 2020·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Matilde LombarderoKalman Kovacs
Sep 29, 2021·Hormones : International Journal of Endocrinology and Metabolism·Yanyan HuGuimei Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basophils

Basophils are myeloid cells with a high affinity IgE receptor and is involved in inflammatory responses during allergy. Discover the latest research on Basophils here.