Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo

Current Biology : CB
P Thomas, Rosa S P Beddington

Abstract

After implantation, the basic body plan of the mammalian embryo is established during gastrulation when the epithelial founder tissue of the fetus, the epiblast, gives rise to new tissues by ingression through the primitive streak. Formation of the primitive streak defines the caudal aspect of the embryo and thus the anteroposterior axis. Further patterning of this axis has been attributed to signals produced by tissues arising from the primitive streak, and in particular the mesendoderm located along the midline of the embryo is thought to be responsible for the correct anteroposterior subdivision of the neurectoderm as it begins to form the central nervous system (CNS). In situ hybridization studies show that the onset of expression of the homeobox-containing gene Hesx1 coincides with the formation of the primitive streak, but occurs on the opposite side of the embryo, in a small domain of anterior endoderm. Lineage tracing using a lipophilic fluorescent label shows that the first endoderm cells to express Hesx1 are not destined to contribute to the future embryo, but instead belong to the primitive endoderm lineage and will be displaced by definitive endoderm arising from the primitive streak during gastrulation. Approximate...Continue Reading

References

Dec 15, 1992·The Journal of Experimental Zoology·R L GardnerD G Altman
Mar 1, 1985·Developmental Biology·C B Kimmel, R D Law
Feb 1, 1971·Experimental Cell Research·D SolterI Damjanov
Aug 1, 1995·Anatomy and Embryology·C ViebahnM Hrabé de Angelis
Nov 1, 1995·Genes & Development·I MatsuoS Aizawa
Mar 30, 1995·Nature·W Shawlot, R R Behringer
May 15, 1995·FEBS Letters·G Chapman, P D Rathjen
Feb 24, 1995·The Journal of Biological Chemistry·P Q ThomasP D Rathjen
Aug 1, 1993·Current Opinion in Genetics & Development·R S Beddington, J C Smith
Dec 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P BouilletP Chambon
Mar 1, 1996·Mechanisms of Development·V Wilson, R S Beddington

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Citations

Nov 20, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·M PesceH R Schöler
Aug 10, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R Brewster, N Dahmane
Nov 1, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Gamse, H Sive
Nov 18, 1997·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Bouwmeester, L Leyns
Feb 12, 2013·Cellular and Molecular Life Sciences : CMLS·Cynthia Lilian Andoniadou, Juan Pedro Martinez-Barbera
Oct 14, 2004·Development Genes and Evolution·Jan IdkowiakChristoph Viebahn
Apr 22, 2011·Development Genes and Evolution·Ana Cristina SilvaJosé António Belo
Jun 26, 2007·Pituitary·Daniel Kelberman, Mehul Tulsidas Dattani
Aug 14, 2012·Pituitary·Sarah J Larkin, Olaf Ansorge
Sep 10, 2005·Reviews in Endocrine & Metabolic Disorders·Karine Rizzoti, Robin Lovell-Badge
Apr 20, 2005·Neurobiology of Disease·Hiroki KurahashiTatsushi Toda
Mar 21, 2003·Developmental Biology·Tomo-o IshikawaMakoto M Taketo
Sep 23, 2003·Developmental Biology·Jaime A Rivera-PérezTerry Magnuson
Oct 22, 2003·Developmental Biology·Ting ChangVolker Hartenstein
Jul 24, 1998·Trends in Genetics : TIG·R S Beddington, E J Robertson
Aug 4, 1999·Trends in Genetics : TIG·C Niehrs
Jan 19, 2000·Trends in Genetics : TIG·B Galliot, D Miller
Mar 16, 2001·Progress in Neurobiology·D AcamporaA Simeone
Nov 2, 2001·Progress in Neurobiology·H Nakamura
Jun 1, 2002·Gene·Fedor EroshkinAndrey Zaraisky
May 30, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·P P BoylA Simeone
Aug 25, 2001·Mechanisms of Development·A Ruiz i AltabaN Dahmane
Jan 13, 1998·Current Opinion in Cell Biology·M Bronner-Fraser, S E Fraser
Jul 13, 2001·Current Opinion in Genetics & Development·C C LuE J Robertson
Aug 17, 1999·Current Opinion in Genetics & Development·R L Gardner
May 6, 1998·Current Opinion in Neurobiology·J L Rubenstein, P A Beachy
Mar 11, 1999·Current Opinion in Neurobiology·M Hynes, A Rosenthal
Sep 13, 2001·Current Biology : CB·T P Yamaguchi
Jun 14, 2000·Clinical Genetics·M T Dattani, I C Robinson
Jan 9, 2009·Nature Reviews. Molecular Cell Biology·Sebastian J Arnold, Elizabeth J Robertson
Sep 29, 2001·Development, Growth & Differentiation·H TiedemannW Knöchel
Mar 29, 2007·Reproduction, Fertility, and Development·Janet Rossant
May 30, 1998·Proceedings of the National Academy of Sciences of the United States of America·W ShawlotR R Behringer
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·J GötzW Kues
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·J HeyerR Kucherlapati
Feb 18, 2012·Stem Cells and Development·Lisa S D Emmett, K Sue O'Shea
May 23, 2012·Stem Cells and Development·Jason T K Hwang, Gregory M Kelly
Nov 13, 1998·Human Molecular Genetics·M WakamiyaR R Behringer
Oct 3, 2009·Human Molecular Genetics·Tanya L HenshallRobert I Richards

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