Anterior retrosplenial cortex is required for long-term object recognition memory.

Scientific Reports
Ana Belén de LandetaCynthia Katche

Abstract

The retrosplenial cortex (RSC) is implicated on navigation and contextual memory. Lesions studies showed that the RSC shares functional similarities with the hippocampus (HP). Here we evaluated the role of the anterior RSC (aRSC) in the "what" and "where" components of recognition memory and contrasted it with that of the dorsal HP (dHP). Our behavioral and molecular findings show functional differences between the aRSC and the dHP in recognition memory. The inactivation of the aRSC, but not the dHP, impairs the consolidation and expression of the "what" memory component. In addition, object recognition task is accompanied by c-Fos levels increase in the aRSC. Interestingly, we found that the aRSC is recruited to process the "what" memory component only if it is active during acquisition. In contrast, both the aRSC and dHP are required for encoding the "where" component, which correlates with c-Fos levels increase. Our findings introduce a novel role of the aRSC in recognition memory, processing not only the "where", but also the "what" memory component.

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Citations

Sep 22, 2020·Brain and Neuroscience Advances·John P Aggleton, Andrew J D Nelson
Feb 14, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sydney TraskFred J Helmstetter
Jun 5, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Anna AmelianchikErin H Norris

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Methods Mentioned

BETA
dissection
Protein Assay

Software Mentioned

Infostat
Graph Pad Prism
Gel
- Pro Analyzer

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