Anterior Segment Seeding in Eyes With Retinoblastoma Failing to Respond to Intraophthalmic Artery Chemotherapy

JAMA Ophthalmology
Efthymia PavlidouMandeep S Sagoo

Abstract

Anterior chamber seeding following intraophthalmic artery chemotherapy is rarely reported. To describe clinicopathologic observations in eyes in which intraophthalmic artery chemotherapy for retinoblastoma failed and to report anterior chamber involvement. A retrospective case series of 12 enucleated eyes (11 patients) with retinoblastoma refractory to intraophthalmic artery chemotherapy between March 1, 2010, and October 31, 2013, at University College London Institute of Ophthalmology and the Retinoblastoma Service, Royal London Hospital. Data analysis was conducted from June 1, 2014, to March 1, 2015. The International Classification of Retinoblastoma groups were B in 1 eye (8%), C in 4 eyes (33%), and D in 7 eyes (58%). Systemic chemotherapy with vincristine sulfate, etoposide, and carboplatin had failed in 10 patients (91%) and 6 eyes (50%) received additional local treatments. In 6 eyes (50%) anterior chamber invasion was clinically detectable. On histopathologic examination, 4 eyes (33%) had no viable retinal tumor; the remainder had poorly differentiated tumor (6 eyes [50%]) or moderately differentiated tumor (2 eyes [17%]). Anterior segment involvement occurred in the ciliary body and/or ciliary muscle (7 eyes [58%]), ...Continue Reading

Citations

Jan 11, 2017·British Medical Bulletin·Marina VasalakiMandeep S Sagoo
Nov 5, 2019·The British Journal of Ophthalmology·Eva Maria BiewaldNikolaos E Bechrakis
Jan 25, 2019·Science Translational Medicine·Guillem Pascual-PastoAngel M Carcaboso
Jul 6, 2021·Case Reports in Ophthalmological Medicine·Babak MasoomianHamid Riazi-Esfahani
Jul 6, 2021·American Journal of Ophthalmology Case Reports·Andrea L BlitzerMichael P Blair
Jun 30, 2021·Clinical & Experimental Ophthalmology·Swathi Kaliki

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