Anterior Skull Base Reconstruction: Does Fat Preparation Matter?

Journal of Neurological Surgery Reports
Joshua WoodCourtney Shires

Abstract

Objectives  This article aims (1) to determine whether there is any difference in cerebrospinal fluid (CSF) leak rate after anterior skull base autologous fat reconstruction based on how the fat is prepared, and (2) to measure impact on surgical times by reconstruction type. Design  Translational animal model surgical technique 3-arm trial, comparing two different methods of autologous fat skull base reconstruction versus a nonreconstructed control group. Setting  Animal study. Subjects  Adult Sprague-Dawley rats. Main Outcome Measures  Resolution of CSF rhinorrhea after repair of a surgically created anterior skull base defect. Results  Both wet (uncompressed) and dry (compressed) fat reconstruction of an anterior skull base defect demonstrated lower CSF leak rates than nonreconstructed defects. Dry fat reconstruction achieved significance in superiority of controlling CSF leak over no reconstruction (64% success vs. 31%); while wet fat reconstruction trended toward significance (50% vs. 31%). Reconstruction procedure time was longer than nonreconstructed controls, but there was no significant difference between type of fat preparation in surgical time. Conclusions  This study demonstrates that drying and compressing the fat g...Continue Reading

Citations

Aug 29, 2019·Current Opinion in Otolaryngology & Head and Neck Surgery·Liliana EinElizabeth A Nicolli
Apr 25, 2020·Brazilian Journal of Otorhinolaryngology·Gustavo Lara RezendeSelma Aparecida Souza Kückelhaus

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BETA
dissection
SISA

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Excel

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