Anterior temporal involvement in semantic word retrieval: voxel-based lesion-symptom mapping evidence from aphasia.

Brain : a Journal of Neurology
Myrna F SchwartzH Branch Coslett

Abstract

Analysis of error types provides useful information about the stages and processes involved in normal and aphasic word production. In picture naming, semantic errors (horse for goat) generally result from something having gone awry in lexical access such that the right concept was mapped to the wrong word. This study used the new lesion analysis technique known as voxel-based lesion-symptom mapping to investigate the locus of lesions that give rise to semantic naming errors. Semantic errors were obtained from 64 individuals with post-stroke aphasia, who also underwent high-resolution structural brain scans. Whole brain voxel-based lesion-symptom mapping was carried out to determine where lesion status predicted semantic error rate. The strongest associations were found in the left anterior to mid middle temporal gyrus. This area also showed strong and significant effects in further analyses that statistically controlled for deficits in pre-lexical, conceptualization processes that might have contributed to semantic error production. This study is the first to demonstrate a specific and necessary role for the left anterior temporal lobe in mapping concepts to words in production. We hypothesize that this role consists in the con...Continue Reading

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Citations

Aug 13, 2013·Brain and Language·Nazbanou Nozari, Gary S Dell
May 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Myrna F SchwartzH Branch Coslett
Jul 1, 2011·Cognitive Neuropsychology·Myrna F Schwartz, Gary S Dell
Sep 2, 2010·Brain : a Journal of Neurology·Solène KalénineHarry Branch Coslett
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