Anterior uveitis and hypotony after intravenous cidofovir for the treatment of cytomegalovirus retinitis

Ophthalmology
M E AklerS C Johnson

Abstract

This study aimed to describe the incidence and risk factors for the development of anterior uveitis in patients receiving intravenous cidofovir for the treatment of longstanding cytomegalovirus retinitis. The study design was a retrospective cohort. Eighteen patients (30 eyes) receiving parenteral cidofovir for the treatment of complicated cytomegalovirus retinitis participated. The clinical response to parenteral cidofovir; the occurrence of anterior uveitis, and the management and outcome of patients with this complication; and the effect of cidofovir on intraocular pressure measurements were measured. There was no progression or relapse of retinitis in patients receiving intravenous cidofovir. Eight (44%) of the 18 patients developed anterior uveitis, which occurred after a median of 4 doses of intravenous cidofovir. The median CD4+ cell count at the time of development of iritis was 101/mm3. Patients who developed uveitis had a mean increase in serum creatinine over baseline measurements (P = 0.05). The use of human immunodeficiency virus type-1 (HIV-1) protease inhibitors was not different between both groups of patients (P = 1.0). The development of anterior uveitis and visually significant hypotony necessitated withdrawa...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·UNKNOWN Studies of Ocular Complications of AIDS Research Group, UNKNOWN AIDS Clinical Trials Group
Jul 1, 1987·Ophthalmology·D A JabsB F Polk
Apr 1, 1987·Ophthalmology·D E HenderlyN A Rao
Oct 2, 1986·Nature·E De ClercqP C Maudgal
Sep 1, 1984·Ophthalmology·A G PalestineR Steis
Feb 1, 1994·The British Journal of Ophthalmology·M Diaz-LlopisF J Romero
Jul 15, 1996·Annals of Internal Medicine·H MasurR Nussenblatt
Mar 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R F Gariano, E L Cooney

❮ Previous
Next ❯

Citations

Jan 5, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J Berenguer, J Mallolas
Sep 29, 2007·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Ajay M TammewarWilliam R Freeman
Apr 26, 2000·AIDS·M LabetoulleJ Gasnault
Jun 14, 2006·International Ophthalmology Clinics·Torsten W Wiegand, Lucy H Y Young
Aug 4, 2005·Retina·Daniel E GoldbergWilliam R Freeman
Sep 30, 1999·The British Journal of Ophthalmology·J AmbatiM R Robinson
Apr 27, 1999·The British Journal of Ophthalmology·H W Henderson, S M Mitchell
Mar 22, 2013·Journal of Ophthalmic Inflammation and Infection·Robert M KnapeJanet L Davis
Mar 26, 2013·Journal of Ophthalmic Inflammation and Infection·Nikolas Js LondonEmmett T Cunningham
Dec 24, 2013·CNS Drugs·Michael S AbersJoseph S Kass
Jan 9, 2003·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Lan WangWilliam G Hodge
Oct 9, 2013·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Oct 18, 2014·Expert Opinion on Drug Safety·Miguel Cordero-ComaTaygan Yilmaz
Jun 19, 2007·Survey of Ophthalmology·Bennie H JengDavid M Meisler
Apr 5, 2002·American Journal of Ophthalmology·UNKNOWN Vitravene Study Group.
Jun 4, 2005·Clinical & Experimental Ophthalmology·Weng T Ng, Patrick Versace
Sep 18, 2018·Current Opinion in Ophthalmology·Ramana S MoorthyEmmett T Cunningham
Jun 5, 2001·The Journal of the Association of Nurses in AIDS Care : JANAC·M G DeGrezia, M Robinson
Feb 8, 2000·Current Opinion in Ophthalmology·M R RobinsonS M Whitcup
May 13, 2020·Ocular Immunology and Inflammation·Remco P H PetersJohn H Kempen
Dec 19, 2019·Ocular Immunology and Inflammation·Ilaria TestiVishali Gupta
Dec 28, 1999·Ocular Immunology and Inflammation·I CochereauT Hoang-Xuan
Feb 8, 2000·Current Opinion in Ophthalmology·R S Moorthy, S Valluri
Mar 11, 2003·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E TacconelliR Cauda
Jan 14, 2021·Survey of Ophthalmology·Maram E A Abdalla Elsayed, Igor Kozak
Feb 22, 2021·Vestnik oftalmologii·O D OstroumovaL K Moshetova
Apr 29, 2019·Survey of Ophthalmology·Qianqian WangDaniel Lee
Jun 5, 2004·Journal français d'ophtalmologie·C Fardeau

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.