Anterior uveitis as a complication of treatment with high dose cytosine-arabinoside

American Journal of Hematology
David PlanerTova Chajek-Shaul

Abstract

We present a case of a 21-year-old woman suffering from diffuse large B-cell lymphoma who developed acute anterior uveitis shortly after completing chemotherapeutic course with HYPER-CVAD protocol (cyclophosphamide, doxorubicin, vincristine, and dexamethasone) alternating with methotrexate and high-dose cytosine-arabinoside (HIDAC), with poor adherence to recommended prophylactic treatment with saline eye drops. Complete resolution of her symptoms was achieved within a few days of treatment with topical steroids. To our knowledge this is the first report of acute anterior uveitis secondary to treatment with HIDAC. Differential diagnosis and a suggested mechanism are discussed.

References

Feb 1, 1983·Cancer·P S RitchD K Heuer
Nov 5, 1997·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·F W Fraunfelder, J T Rosenbaum
Oct 24, 1997·Advances in Cancer Research·S Grant
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D A ThomasH Kantarjian
Sep 21, 2000·European Journal of Haematology·J SchwartzA Lowenstein
Feb 13, 2001·Ophthalmology·A RothovaH M Lokhorst

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Citations

Oct 16, 2012·Annals of Hematology·Hatem KremaCharles J Pavlin
Oct 6, 2009·Acta Ophthalmologica·Johan MobergGabor Koranyi
Oct 5, 2010·Ocular Immunology and Inflammation·Robert E FintelmannBennie H Jeng

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