Anterograde axonal transport, transcytosis, and recycling of neurotrophic factors: the concept of trophic currencies in neural networks

Molecular Neurobiology
Christopher S von BartheldRafal Butowt

Abstract

Traditional views of neurotrophic factor biology held that trophic factors are released from target cells, retrogradely transported along their axons, and rapidly degraded upon arrival in cell bodies. Increasing evidence indicates that several trophic factors such as brain-derived neurotrophic factor (BDNF), fibroblast growth factor (FGF-2), glial cell-line derived neurotrophic factor (GDNF), insulin-like growth factor (IGF-I), and neurotrophin-3 (NT-3), can move anterogradely along axons. They can escape the degradative pathway upon internalization and are recycled for future uses. Internalized ligands can move through intermediary cells by transcytosis, presumably by endocytosis via endosomes to the Golgi system, by trafficking of the factor to dendrites or by sorting into anterograde axonal transport with subsequent release from axon terminals and uptake by second- or third-order target neurons. Such data suggest the existence of multiple "trophic currencies," which may be used over several steps in neural networks to enable nurturing relationships between connected neurons or glial cells, not unlike currency exchanges between trading partners in the world economy. Functions of multistep transfer of trophic material through ...Continue Reading

References

Sep 25, 2009·Experimental Brain Research·Kurt GottmannVolkmar Lessmann
Sep 30, 2005·Anatomy and Embryology·Carla LuciniLuciana Castaldo
Apr 15, 2004·Molecular and Cellular Neurosciences·Gabriela Chytrova, James E Johnson
Jun 6, 2003·Progress in Neurobiology·Volkmar LessmannMarzia Malcangio
Dec 31, 2003·Molecular and Cellular Neurosciences·Elisabetta MennaLamberto Maffei
May 14, 2003·Progress in Retinal and Eye Research·Stefan IsenmannAlessandro Cellerino
Dec 4, 2012·Acta Pharmacologica Sinica·Philippe M D'Onofrio, Paulo D Koeberle
Sep 18, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masatoshi SuzukiClive N Svendsen
Sep 9, 2006·Journal of Neurotrauma·David J PhillipsMaria C Morganti-Kossmann
Feb 3, 2012·Proceedings. Biological Sciences·Peter G H Clarke
Aug 16, 2006·Neuro-degenerative Diseases·Eva Ekestern
Jun 20, 2012·Molecular Neurodegeneration·Cheng FangGary Banker
May 22, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anne Marie Wissman, Eliot A Brenowitz
Jul 11, 2006·Neuro-Signals·Klaus HeeseNoriko Inoue
Apr 23, 2005·Progress in Retinal and Eye Research·Rafael LindenMariana S Silveira
Aug 7, 2004·Brain Research. Brain Research Reviews·Weihong Pan, Abba J Kastin
Sep 22, 2015·Frontiers in Neuroscience·Josephine PinkernelleGerburg Keilhoff
Jul 26, 2016·Frontiers in Neuroanatomy·Clara Ortega-de San Luis, Alberto Pascual
Nov 24, 2007·Acta histochemica·Lucianna MaruccioLuciana Castaldo
Sep 2, 2010·Experimental Eye Research·Pamela B YangHans S Keirstead
Jun 23, 2004·Molecular and Cellular Neurosciences·Smita SaxenaAlex Krüttgen
Aug 21, 2010·Brain, Behavior, and Immunity·Junping XinKathryn J Jones
Jan 14, 2017·Translational Research : the Journal of Laboratory and Clinical Medicine·Il-Shin LeeKook In Park
May 4, 2005·Molecular and Cellular Neurosciences·Rafal Butowt, Christopher S von Bartheld
Jun 16, 2009·Neuroscience Research·Volkmar Lessmann, Tanja Brigadski
Jul 23, 2013·Movement Disorders : Official Journal of the Movement Disorder Society·Juan Ramirez-CastanedaZoltan Mari
Oct 28, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Lara D HutsonChi-Bin Chien
Apr 26, 2002·Neuroreport·Howard B Rind, Christopher S von Bartheld
Jan 6, 2004·Journal of Neurobiology·Christopher S von Bartheld

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