Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system

Nature
C S Von BartheldM Bothwell

Abstract

Neurotrophic factors support the differentiation and survival of neurons and influence properties of synaptic transmission. The neurotrophic hypothesis postulates a retrograde action of trophic factors: their production and release by target cells and their uptake by innervating axons. Besides the retrograde route of trophic messengers, the survival of neurons and the development of synapses is thought to be also regulated by anterograde, afferent trophic signals. We now show that exogenous neurotrophins are transported in the anterograde direction, from cell bodies to the axon terminals, and that the intact neurotrophin is released after anterograde transport, taken up and utilized by second-order visual neurons in the developing chick brain. These results suggest that anterogradely transported neurotrophins may play a role in synaptic plasticity and may have effects at more than one synapse beyond the initial release site.

References

Sep 1, 1992·Trends in Neurosciences·S O Meakin, E M Shooter
May 1, 1991·Trends in Neurosciences·H Thoenen
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Jun 1, 1989·Neuron·Y A Barde
Dec 1, 1993·Journal of Neuroscience Research·M P Nieto-BonaI Torres-Aleman
Jan 1, 1995·Annual Review of Neuroscience·M Bothwell

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Citations

Dec 22, 1999·The Journal of Comparative Neurology·C R BuckT C Cope
Aug 22, 2001·Microscopy Research and Technique·E A Debski
Apr 15, 2004·Molecular and Cellular Neurosciences·Gabriela Chytrova, James E Johnson
Dec 22, 1998·Brain Research. Brain Research Reviews·M DeschênesZ W Zhang
Apr 7, 2000·Brain Research. Brain Research Reviews·R Linden
Jun 20, 2001·Brain Research. Developmental Brain Research·S Heidmann, H Luksch
Dec 14, 2002·Brain Research. Developmental Brain Research·Maree J WebsterJoel E Kleinman
Jan 4, 2001·Trends in Neurosciences·A F Schinder, M Poo
Oct 24, 1998·Trends in Neurosciences·C A Altar, P S DiStefano
Jul 10, 2002·Neuroscience Research·Masami KojimaHiroshi Hatanaka
Nov 19, 1997·Neurochemistry International·M Knipper, R J Rylett
Jun 6, 2003·Progress in Neurobiology·Volkmar LessmannMarzia Malcangio
Feb 13, 1999·Progress in Neurobiology·M J Millan
Nov 19, 2003·Neuroscience Letters·Jean-Dominique DelcroixPaul Fernyhough
Jan 13, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S CubillosL Lima
Sep 9, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Hafidi

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