DOI: 10.1101/19011825Nov 14, 2019Paper

Anterolateral entorhinal cortex thickness as a new biomarker for early detection of Alzheimer's disease

MedRxiv : the Preprint Server for Health Sciences
A. HolbrookD. Gillen

Abstract

Introduction: Loss of entorhinal cortex (EC) layer II neurons represents the earliest AD lesion in the brain. Research suggests differing functional roles between two EC subregions, the anterolateral EC (aLEC) and the posteromedial EC (pMEC). Methods: We use joint label fusion to obtain aLEC and pMEC cortical thickness measurements from serial MRI scans of 775 ADNI-1 participants (219 healthy; 380 MCI; 176 AD) and use linear mixed-effects models to analyze longitudinal associations between cortical thickness, disease status and cognitive measures. Results: Group status is reliability predicted by aLEC thickness, which also exhibits greater associations with cognitive outcomes than does pMEC thickness. Change in aLEC thickness is also associated with CSF amyloid and tau levels. Discussion: Thinning of aLEC is a sensitive structural biomarker that changes over short durations in the course of AD and tracks disease severity; it is a strong candidate biomarker for detection of early AD.

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