PMID: 3745874Sep 1, 1986Paper

Anthelmintic activity of triclabendazole

Journal of Helminthology
G C Coles

Abstract

Triclabendazole was tested in vitro and in vivo against a range of helminths. Although in vitro activity was found against Hymenolepis diminuta (0.5 microgram/ml), Fasciola hepatica (2.5 micrograms/ml), Taenia crassiceps and Schistosoma mansoni (50 micrograms/ml), in vivo activity was only found against F. hepatica, a single oral dose of 40 mg/kg killing 99% of adult flukes in the rat. This spectrum of activity suggests a mechanism of action unlike that of other benzimidazole anthelmintics.

References

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Sep 1, 1960·British Journal of Pharmacology and Chemotherapy·A B SEN, F HAWKING

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Citations

Apr 1, 1995·International Journal for Parasitology·A W StittR O Mackender
Dec 23, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M CalvopiñaP J Cooper
Oct 8, 2013·Parasitology Research·Serry A El BialyHassan M Essa
Mar 1, 1992·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S PicotP Ambroise-Thomas
Nov 26, 2005·Expert Opinion on Investigational Drugs·Jennifer KeiserJürg Utzinger
Apr 2, 2005·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L MottierC Lanusse
Feb 7, 2016·Asian Pacific Journal of Tropical Medicine·Ana Vargas-CallaArmando E Gonzalez
Jul 1, 1991·The British Veterinary Journal·Q A McKellar, L D Kinabo
Mar 1, 1990·The British Veterinary Journal·G C Coles
Mar 12, 2016·Journal of Wildlife Diseases·Saša M TrailovićZoran Kulišić
Sep 18, 1999·The Veterinary Journal·I Fairweather, J C Boray
May 31, 2016·Parasitology International·Timir TripathiBanchob Sripa
May 27, 2020·ACS Omega·Tripti PandeyTimir Tripathi

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