Anthelmintic efficacy of Achillea millifolium against gastrointestinal nematodes of sheep: in vitro and in vivo studies

Journal of Helminthology
K A TariqA S Shawl

Abstract

Achillea millifolium Linn., commonly called 'Pehl-ghasa', is used by farmers in traditional animal health care as a vermifuge. The objective of this study was to evaluate the anthelmintic efficacy of crude aqueous extracts and crude ethanolic extracts of entire A. millifolium against the gastrointestinal nematodes of sheep. The worm motility inhibition assay was used for in vitro studies and faecal egg count reduction assay was used for in vivo studies. In vitro studies revealed significant anthelmintic effects of aqueous extracts and ethanolic extracts on live Haemonchus contortus worms (P < 0.05) as evident from their paralysis and/or death at 8 h post exposure. Aqueous extracts of A. millifolium resulted in a mean worm motility inhibition of 94.44%, while ethanolic extracts resulted in mean worm motility inhibition of 88.88%. The mean mortality index of aqueous extracts was 0.95 while for ethanolic extracts it was 0.9. The lethal concentration 50 was 0.05 mg ml(-1) for aqueous extracts and 0.11 mg ml(-1) for ethanolic extracts. The in vivo anthelmintic activity of aqueous and ethanolic extracts of A. millifolium demonstrated a maximum (88.40%) nematode egg count reduction in sheep treated with aqueous extracts at 2 g kg(-1) ...Continue Reading

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Citations

May 12, 2012·Parasitology Research·Suman KunduLarisha M Lyndem
Jun 7, 2011·Tropical Animal Health and Production·Viola Maphosa, Patrick J Masika
Oct 16, 2012·Tropical Animal Health and Production·Bashir A LoneHumeera Nisa
Jul 25, 2017·Tropical Animal Health and Production·Bashir A LoneAbida Khan
Jun 16, 2017·Phytotherapy Research : PTR·Sofi Imtiyaz AliV Venkatesalu
Nov 24, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Rama AggarwalUpma Bagai
Jan 15, 2021·Comprehensive Reviews in Food Science and Food Safety·Jonas Joaquim Mangabeira da SilvaJonas Augusto Rizzato Paschoal

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics (ASM)

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