Anthelmintic efficacy of Moringa oleifera seed methanolic extract against Fasciola hepatica

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Omnia M KandilMargarita Gabrashanska

Abstract

The current study was carried out to assess in vitro and in vivo effects of Moringa oleifera seed methanolic extract on Fasciola hepatica to develop an alternative source of treatment. The in vitro ovicidal effect of M. oleifera seed extract on immature F. hepatica eggs has provided evidence of inhibitory activity on the vitality and hatchability of F. hepatica eggs. This inhibitory activity was concentration-dependent and also correlated strongly with the exposure time. In the in vivo trial, the oral administration of F. hepatica experimentally infected rabbits with doses of 150 mg/kg BW prepared extract per day for 3 consecutive days on the 63rd day post infection confirmed potent fasciolicide activity of the extract. A gradual decrease in fecal egg count (FEC) was detected from the 1st day post treatment until reaching 100% FEC reduction by the 7th day post treatment. No flukes could be found at post mortem examinations. Significant increments of serum total protein, globulin, the activities of ALT and AST, total cholesterol, triglycerides and urea were recorded during the period of infection, which were improved by treatment. Remarkable histopathological alterations were observed in the infected liver and gallbladder tissue...Continue Reading

References

Aug 1, 1979·The Australian Journal of Experimental Biology and Medical Science·C B ChapmanG F Mitchell
Oct 1, 1992·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·M Aminlari, T Vaseghi
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Apr 1, 1967·Experimental Parasitology·S B KendallM A Peirce
Jan 5, 2002·Veterinary Parasitology·W M LotfyH F Farag
Jul 1, 1957·American Journal of Clinical Pathology·S REITMAN, S FRANKEL
Jun 1, 1960·Annals of Tropical Medicine and Parasitology·S A ROWCLIFFE, C B OLLERENSHAW
Jun 4, 2010·Anais Brasileiros De Dermatologia·Paulo Ricardo CriadoCarlos d'Apparecida Machado Filho
Oct 16, 2012·Tropical Animal Health and Production·Ana Mbokeleng TsotetsiJaison Mpofu
Nov 10, 2015·Experimental Parasitology·María Victoria SolanaHugo Daniel Solana
Apr 7, 2016·Trends in Parasitology·Jane M KelleyTerry W Spithill
Apr 12, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Hatem A ShalabyReem O A Kamel
Sep 9, 2016·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Mohammad Moazeni, Ali Asghar Khademolhoseini
Apr 12, 2017·International Journal of Veterinary Science and Medicine·Delfin E Cabardo, Harvie P Portugaliza

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Citations

Aug 14, 2019·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Dina AboelsouedSally Ibrahim

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Anthelmintics (ASM)

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