Anthocyanins and metabolites from purple rice inhibit IL-1β-induced matrix metalloproteinases expression in human articular chondrocytes through the NF-κB and ERK/MAPK pathway

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Tunchanok WongwichaiPeraphan Pothacharoen

Abstract

Osteoarthritis (OA) is a common degenerative joint disease, which is closely related to cartilage degradation. Anthocyanins, a natural flavonoid pigments, exhibit strong antioxidant and anti-inflammatory properties. However, the effect of anthocyanin on inflammatory response in OA has not been investigated. Our results showed that cyanidin-3-O-glucoside (C3G) and peonidin-3-O-glucoside (P3G), the main anthocyanins found in three Thai purple rice cultivars, attenuated the inhibition of porcine cartilage degradation in an experimental model. The effects of three Thai purple rice extracts were related to their high concentration of anthocyanins. Moreover, protocatechuic acid (PA), the main metabolite of anthocyanin, has chondroprotective potential by reducing glycosaminoglycans and collagen breakdown in IL-1β/OSM-induced porcine cartilage explants in long-term condition. The induction of matrix metalloproteinases (MMPs) caused by IL-1β-stimulated human chondrocytes was also attenuated by C3G, P3G, and their metabolites. Furthermore, C3G, P3G, and their metabolites pretreatment significantly inhibited IκBα degradation, the level of p-p65, and ERK/MAPK pathway. Additionally, PA pretreatment enhanced the phosphorylation of JNK in IL-...Continue Reading

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Citations

Nov 22, 2019·Journal of Food Science and Technology·Pablo R DuchowiczAlicia B Pomilio
Apr 29, 2020·Antioxidants·Georgia-Eirini DeligiannidouTheodoros Constantinides
May 30, 2019·International Journal of Molecular Sciences·Shiyu LiLavanya Reddivari
Jun 24, 2020·Journal of Orthopaedic Surgery and Research·Zhi-Xi DuanZhi-Hong Li
Jun 25, 2019·Oxidative Medicine and Cellular Longevity·Fang-Fang SunLi-Dong Wu
Nov 18, 2020·Journal of Biomolecular Structure & Dynamics·Mala RajendranIvo Provaznik
Jun 3, 2021·Antioxidants·Supapohn Yamuangmorn, Chanakan Prom-U-Thai
Aug 2, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jiao SongDingkun Zhang
May 1, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Zubeyir ElmazogluÇimen Karasu

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