Anthocyanins and Phenolic Acids of Hybrid and Native Blue Maize (Zea mays L.) Extracts and Their Antiproliferative Activity in Mammary (MCF7), Liver (HepG2), Colon (Caco2 and HT29) and Prostate (PC3) Cancer Cells

Plant Foods for Human Nutrition
D A Urias-LugoJ A Gutiérrez-Uribe

Abstract

Blue maize is an excellent source of bioactive components such as phenolic acids and anthocyanins but when it is processed for human consumption, these compounds decrease considerably. Therefore, blue maize could be directed to produce nutraceutical extracts. The aim of this study was to evaluate the relation between anthocyanins composition of acidified and non-acidified extracts from native and hybrid blue maize genotypes and their antiproliferative effect in mammary (MCF7), liver (HepG2), colon (Caco2 and HT29) and prostate (PC3) cancer cells. The most abundant phenolic acid was ferulic acid. Nine anthocyanins were quantified in the extracts, being Cy3-Glu the most abundant. Acylated forms were also obtained in high abundance depending of the extraction method. An extract concentration range of 4.31 to 7.23 mg/mL inhibited by 50% the growth of untransformed cells NIH3T3. Antiproliferative effect on PC3, Caco2, HepG2 and MCF7 cancer cells of acidified extracts from hybrid blue maize was larger than the observed using non-acidified extracts. Among the nine compounds that were quantified in the extracts tested, CyMalGlu I showed the strongest correlation with the reduction of cell viability in Caco2 (-0.876), HepG2 (-0.813), MC...Continue Reading

References

Aug 9, 2002·Journal of Agricultural and Food Chemistry·Veronica DewantoRui Hai Liu
Jun 22, 2006·Journal of Agricultural and Food Chemistry·El-Sayed M Abdel-AalIwona Rabalski
Jun 24, 2008·Cancer Letters·Li-Shu Wang, Gary D Stoner
Aug 1, 2008·Current Clinical Pharmacology·Kathryn A RoupeNeal M Davies
Jan 18, 2012·Journal of Agricultural and Food Chemistry·Slađana ZilićJelena Vančetović
Sep 5, 2014·Plant Foods for Human Nutrition·Marilena Antunes-RicardoSergio O Serna-Saldivar

❮ Previous
Next ❯

Citations

Oct 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rebeca García-VarelaGuy A Cardineau
Dec 24, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Oscar Aguilar, Carmen Hernández-Brenes
Jun 11, 2016·Food Chemistry·Gustavo A Camelo-MéndezLuis A Bello-Pérez
May 12, 2016·Plant Foods for Human Nutrition·Juan-Ying OuShi-Yi Ou
May 28, 2016·Physiologia Plantarum·Xianzhi HeDe-Yu Xie
Sep 23, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Francisco J Olivas-AguirreAbraham Wall-Medrano
Jan 18, 2018·Plant Foods for Human Nutrition·Leilson O RibeiroSuely P Freitas
Aug 24, 2019·Nature Reviews. Gastroenterology & Hepatology·Ju Dong YangLewis R Roberts
Aug 8, 2017·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Dragan R MilićevićSaša Janković
Mar 4, 2020·Annual Review of Food Science and Technology·Elvira Gonzalez de MejiaMary Ann Lila
Jul 21, 2020·Critical Reviews in Food Science and Nutrition·Praveen SainiVijay Singh
Jul 26, 2018·Journal of Food Science and Technology·Gustavo A Camelo-MéndezLuis A Bello-Pérez
Feb 10, 2019·Plant Foods for Human Nutrition·Christian Denisse Chavarín-MartínezCuauhtémoc Reyes-Moreno
Sep 28, 2018·G3 : Genes - Genomes - Genetics·Michael N PaulsmeyerJohn A Juvik
Nov 20, 2019·Journal of Food Science and Technology·Leilson de Oliveira RibeiroSuely Pereira Freitas
Mar 12, 2020·Food Research International·Rebeca Salvador-Reyes, Maria Teresa Pedrosa Silva Clerici
Mar 1, 2017·Comprehensive Reviews in Food Science and Food Safety·Fei LaoM Mónica Giusti
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Natalia Palacios-RojasSherry A Tanumihardjo
Sep 27, 2019·Food Research International·Tatiana Porto Santos, Rosiane Lopes Cunha

❮ Previous
Next ❯

Related Concepts