Anthocyanins, multi-functional natural products of industrial relevance: Recent biotechnological advances

Biotechnology Advances
Tarun BelwalZisheng Luo

Abstract

Anthocyanins, the color compounds of plants, are known for their wide applications in food, nutraceuticals and cosmetic industry. The biosynthetic pathway of anthocyanins is well established with the identification of potential key regulatory genes, which makes it possible to modulate its production by biotechnological means. Various biotechnological systems, including use of in vitro plant cell or tissue cultures as well as microorganisms have been used for the production of anthocyanins under controlled conditions, however, a wide range of factors affects their production. In addition, metabolic engineering technologies have also used the heterologous production of anthocyanins in recombinant plants and microorganisms. However, these approaches have mostly been tested at the lab- and pilot-scales, while very few up-scaling studies have been undertaken. Various challenges and ways of investigation are proposed here to improve anthocyanin production by using the in vitro plant cell or tissue culture and metabolic engineering of plants and microbial culture systems. All these methods are capable of modulating the production of anthocyanins , which can be further utilized for pharmaceutical, cosmetics and food applications.

Citations

Dec 23, 2020·Natural Product Reports·Philippe JeandetSeyed Mohammad Nabavi
Jan 15, 2021·International Journal of Molecular Sciences·Zdeněk KejíkMilan Jakubek
Apr 1, 2021·Journal of Food Biochemistry·Tatiane de Oliveira Xavier MachadoMarcos Dos Santos Lima
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ceferino CarreraMiguel Palma
Jul 29, 2021·Plant Science : an International Journal of Experimental Plant Biology·Rui ChenXiaoyan Cao

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