Anthracene Bisureas as Powerful and Accessible Anion Carriers

Chemistry : a European Journal
Christopher M DiasAnthony P Davis

Abstract

Synthetic anion carriers (anionophores) have potential as biomedical research tools and as treatments for conditions arising from defective natural transport systems (notably cystic fibrosis). Highly active anionophores that are readily accessible and easily deliverable are especially valuable. Previous work has resulted in steroid and trans-decalin based anionophores with exceptional activity for chloride/nitrate exchange in vesicles, but poor accessibility and deliverability. This work shows that anthracene 1,8-bisureas can fulfil all three criteria. In particular, a bis-nitrophenyl derivative is prepared in two steps from commercial starting materials, yet shows comparable transport activity to the best currently known. Moreover, unlike earlier highly active systems, it does not need to be preincorporated in test vesicles but can be introduced subsequent to vesicle formation. This transporter also shows the ability to transfer between vesicles, and is therefore uniquely effective for anion transport at low transporter loadings. The results suggest that anthracene bisureas are promising candidates for application in biological research and medicine.

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Jan 30, 2018·Organic & Biomolecular Chemistry·Christopher M DiasAnthony P Davis

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Citations

Mar 30, 2019·Angewandte Chemie·Glenn GrauwelsKristin Bartik
Nov 27, 2019·Chemical Communications : Chem Comm·Alberto FuertesJuan R Granja
Jul 22, 2020·Chemical Society Reviews·Jeffery T DavisRoberto Quesada
Apr 23, 2021·Chemical Communications : Chem Comm·Xin Wu, Philip A Gale
Jun 8, 2021·Frontiers in Chemistry·Krystyna Maslowska-JarzynaMichał J Chmielewski
Sep 16, 2021·Organic & Biomolecular Chemistry·Luis Martínez-CrespoHennie Valkenier

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