Anthracyclines in the treatment of gynecologic malignancies

Gynecologic Oncology
F C Maluf, D R Spriggs

Abstract

The purpose of this article is to present a summary of the pharmacology of anthracyclines as well as to review the results of clinical trials including patients with gynecologic malignancies treated with anthracycline-based therapy. We performed a MEDLINE literature search of relevant clinical trials for the scope of this review that evaluated anthracycline-based therapy in gynecologic malignancies. Doxorubicin has established activity in carcinomas that arise in the ovary, uterine cervix, and endometrium as well as in uterine sarcomas. However, doxorubicin has structural characteristics that limit its efficacy and safety. Newer anthracyclines with distinct structure, pharmacokinetics, pharmacodynamics, and toxicity profiles have been developed to overcome the limitations of doxorubicin and to further exploit the activity of anthracyclines. Epirubicin is characterized by a structural formula that confers similar cytotoxic antitumor activity with fewer associated side effects than its analogue. Most recently, pegylated liposomal formulations, with distinct pharmacokinetic properties and a favorable toxicity profile, have shown antitumor activity as salvage therapy in ovarian cancer. Intraperitoneal mitoxantrone is also associate...Continue Reading

References

Jan 1, 1979·Journal of Surgical Oncology·M S PiverR Yazigi
Jun 1, 1977·American Journal of Obstetrics and Gynecology·F M MuggiaS L Romney
Aug 14, 1992·Biochimica Et Biophysica Acta·M C Woodle, D D Lasic
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R ColemanP Harper
Nov 2, 1990·Biochimica Et Biophysica Acta·G Blume, G Cevc
Apr 1, 1989·American Journal of Clinical Oncology·H B MussW A Christopherson
Apr 1, 1989·Cancer·L C WongH K Ma
Jul 1, 1988·Clinical Pharmacokinetics·P A SpethC Haanen
Sep 21, 1988·Journal of the National Cancer Institute·L GianniV Malatesta
Nov 1, 1987·The Australian & New Zealand Journal of Obstetrics & Gynaecology·D J Boadle, M H Tattersall
Oct 1, 1984·American Journal of Clinical Oncology·R D HilgersD S Alberts
Jan 1, 1982·Cancer Chemotherapy and Pharmacology·N SavarajT L Loo
Jan 1, 1994·Journal of Drug Targeting·M C WoodleJ A Cohen
Jan 1, 1995·Cancer Chemotherapy and Pharmacology·M O NicolettoM V Fiorentino
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M O NicolettoS Monfardini
May 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·I PeláezJ Fra
Aug 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E van der BurgJ B Vermorken

❮ Previous
Next ❯

Citations

Apr 20, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Vicky MakkerCarol A Aghajanian
May 22, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Y YildirimS Tinar
Nov 28, 2013·Cellular Oncology (Dordrecht)·Fatemeh BagheriNader Sheibani
Mar 15, 2011·The Breast : Official Journal of the European Society of Mastology·Silvia DellapasquaMarco Colleoni
Oct 20, 2015·Ultrasound in Medicine & Biology·Maxime LafondCyril Lafon
Feb 19, 2005·Seminars in Oncology·David S AlbertsAlberto A Gabizon
Jul 25, 2006·Expert Opinion on Pharmacotherapy·Maurie Markman
Sep 8, 2011·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Aneta RogalskaAgnieszka Marczak
Sep 10, 2003·Hematology/oncology Clinics of North America·Vicki V Baker
Feb 3, 2007·Chemical & Pharmaceutical Bulletin·Hsu-Shan HuangJing-Jer Lin
Sep 19, 2003·The Oncologist·Joyce O'Shaughnessy
Sep 19, 2003·The Oncologist·Tamar Safra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinosarcoma

Carcinosarcoma is a malignant neoplasm that contains elements of carcinoma and sarcoma so extensively intermixed as to indicate neoplasia of epithelial and mesenchymal tissue. Discover the latest research on carcinosarcoma here.