Anthranilate sulfonamide hydroxamate TACE inhibitors. Part 1: Structure-based design of novel acetylenic P1' groups

Bioorganic & Medicinal Chemistry Letters
James M ChenJeremy Levin

Abstract

The structure-based design of potent sulfonamide hydroxamate TACE inhibitors bearing novel acetylenic P1' groups has led to compounds with excellent in vitro potency against TACE and selectivity over MMP-1.

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Aug 22, 2001·Bioorganic & Medicinal Chemistry Letters·J I LevinJ S Skotnicki
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Oct 26, 2001·Bioorganic & Medicinal Chemistry Letters·J I LevinJ S Skotnicki
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Citations

Mar 10, 2004·Bioorganic & Medicinal Chemistry Letters·Takahiro TsukidaShin-Ichiro Nishimura
Mar 5, 2005·Bioorganic & Medicinal Chemistry Letters·Arie ZaskJerauld Skotnicki
Apr 2, 2003·Bioorganic & Medicinal Chemistry Letters·A ZaskJ S Skotnicki
Jul 23, 2003·Bioorganic & Medicinal Chemistry Letters·J I LevinJ S Skotnicki
Sep 3, 2003·Bioorganic & Medicinal Chemistry Letters·Michael A LetavicChul H Yu
Sep 25, 2010·Journal of Molecular Graphics & Modelling·Eamonn F HealyGunnar Lindfors
May 22, 2010·Chemical Biology & Drug Design·Malkeet S Bahia, Om Silakari
Nov 24, 2004·Drug Design and Discovery·Jeremy I Levin, Mila T Du
Apr 6, 2002·Bioorganic & Medicinal Chemistry Letters·J I LevinJ S Skotnicki
Sep 11, 2004·Bioorganic & Medicinal Chemistry Letters·Chu-Biao XueCarl P Decicco
Aug 9, 2005·Bioorganic & Medicinal Chemistry Letters·J I LevinJ S Skotnicki
May 29, 2007·Bioorganic & Medicinal Chemistry Letters·Henry-Georges LombartJeremy Levin
Sep 16, 2008·Bioorganic & Medicinal Chemistry·Dimitris Georgiadis, Athanasios Yiotakis
Jun 6, 2003·Medicinal Research Reviews·Claudiu T SupuranAndrea Scozzafava
Nov 12, 2005·Medicinal Research Reviews·Gerd Wagner, Stefan Laufer
Mar 7, 2006·Bioorganic & Medicinal Chemistry Letters·John L GilmoreJames J-W Duan
Dec 20, 2008·Bioorganic & Medicinal Chemistry·Shirshendu DasGuptaMange Ram Yadav

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