PMID: 9435110Jan 22, 1998Paper

Anthrax lethal toxin-induced mitogenic response of human T-cells

FEMS Microbiology Letters
C Guidi-RontaniM Mock

Abstract

Bacillus anthracis lethal toxin (PALF) stimulated the proliferation of human peripheral blood T-cells in vitro. Activation of T-lymphocytes by PALF required the presence of monocytes and did not result from a collaborative effect between T-cells and B-cells. PALF acted directly on monocytes and independently of T-cells. The monocytes contributed to the proliferation of T-cells by secretion of mediator(s). The mitogenic activity of the lethal toxin was dependent on its metalloprotease activity.

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Citations

Feb 13, 1999·Molecular Microbiology·C Guidi-RontaniM Mock
Dec 12, 2001·Molecular Microbiology·C Guidi-RontaniM Mock
Feb 24, 2001·Cellular Microbiology·C Guidi-RontaniV Cabiaux
Mar 18, 2000·Infection and Immunity·F BrossierJ C Sirard
Jun 7, 2005·Advanced Drug Delivery Reviews·Robert N Brey
Nov 1, 2011·Toxins·Eric K DumasA Darise Farris

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