Abstract
Non-alcoholic fatty liver disease (NAFLD) comprises non-progressive steatosis and non-alcoholic steatohepatitis (NASH), the latter of which may cause cirrhosis and hepatocellular carcinoma (HCC). As NAFLD detection is imperative for the prevention of its complications, we evaluated whether a combination of blood-based biomarkers and anthropometric parameters can be used to predict NAFLD among overweight and obese adults. 143 overweight or obese non-smokers free of diabetes (50% women, age: 35-65 years) were recruited. Anthropometric indices and routine biomarkers of metabolism and liver function were measured to predict magnetic resonance (MR) - derived NAFLD by multivariable logistic regression models. In addition, we evaluated to which degree the use of more novel biomarkers (adiponectin, leptin, resistin, C-reactive protein, TNF-α, IL-6, IL-8 and interferon-γ) could improve prediction models. NAFLD was best predicted by a combination of age, sex, waist circumference, ALT, HbA1c, and HOMA-IR at an area under the receiver operating characteristic curve (AUROC) of 0.87 (95% CI: 0.81, 0.93) before and 0.85 (95% CI: 0.78, 0.91) after internal bootstrap validation. The use of additional biomarkers of inflammation and metabolism di...Continue Reading
References
Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lidia S SzczepaniakRobert L Dobbins
Nov 4, 2006·BMC Gastroenterology·Giorgio BedogniClaudio Tiribelli
Feb 20, 2007·Acta Paediatrica·Lucia PacificoAndrea Laghi
May 15, 2007·Obesity·Samuel KleinRichard Kahn
Jun 16, 2009·Gastroenterology·Anna KotronenHannele Yki-Järvinen
Jul 30, 2009·Gastroenterology·Naga Chalasani
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jeong-Hoon LeeHyo-Suk Lee
May 13, 2010·Digestive Diseases·Beate Katharina Straub, Peter Schirmacher
Aug 4, 2010·European Radiology·Anneloes E BohteJaap Stoker
Aug 27, 2010·BMC Gastroenterology·Giorgio BedogniClaudio Tiribelli
Jul 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Geraldine H KangClaude B Sirlin
Apr 3, 2013·Genomics·Adviti NaikDamjana Rozman
May 25, 2013·American Journal of Epidemiology·Mariana LazoJeanne M Clark
Sep 18, 2013·Nature Reviews. Gastroenterology & Hepatology·Rohit Loomba, Arun J Sanyal
Sep 26, 2013·Nature Reviews. Gastroenterology & Hepatology·Laurent CasteraPaul Angulo
Dec 11, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaodong ZhongMustafa R Bashir
Feb 28, 2014·World Journal of Gastroenterology : WJG·Yoshio SumidaYoshito Itoh
Aug 26, 2014·World Journal of Gastroenterology : WJG·Emer Fitzpatrick, Anil Dhawan
Sep 23, 2014·BMJ : British Medical Journal·Naveed SattarDavid Preiss
Jan 13, 2015·Canadian Journal of Gastroenterology & Hepatology·Manuela G NeumanRadu M Nanau
Apr 29, 2015·Journal of Hepatology·Christopher D Byrne, Giovanni Targher
Dec 1, 2013·Hepatology International·Ajay Duseja, Naga Chalasani
Sep 6, 2015·European Radiology·Holger HetterichFabian Bamberg
Apr 6, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michelle T LongCaroline S Fox
Apr 12, 2016·Clinics in Liver Disease·William N Hannah, Stephen A Harrison
May 18, 2016·International Journal of Molecular Sciences·Claudia SannaElisabetta Bugianesi
Jan 1, 2015·Nature Reviews. Disease Primers·Elizabeth M BruntMary E Rinella
Sep 14, 2016·World Journal of Gastroenterology : WJG·Ivana MikolasevicSandra Milic
Oct 30, 2016·Contemporary Clinical Trials·Ruth SchübelTilman Kühn
Oct 1, 2016·World Journal of Gastroenterology : WJG·Laurence J BrittonDarrell Hg Crawford
Dec 6, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S HeebøllA Handberg
Citations
Apr 26, 2019·Nutrients·Yixin JiangJohanna Nattenmüller
Mar 11, 2020·BMJ Open·Verena KatzkeRudolf Kaaks
Apr 5, 2020·Nutrients·Cora WatzingerTilman Kühn
May 28, 2020·Nutrients·Manuela SpurnyJohanna Nattenmüller
Aug 23, 2020·Antioxidants·Margalida Monserrat-MesquidaAntoni Sureda
Jun 2, 2020·Current Genomics·Lu ZengZhengwen Liu
Mar 22, 2019·Phytotherapy Research : PTR·Alireza GheflatiAzadeh Nadjarzadeh
Oct 4, 2020·Diabetes/metabolism Research and Reviews·Francisca Dos Santos CoelhoAdelino Leite-Moreira
Apr 5, 2020·Experimental and Molecular Pathology·Shusei YamamotoShogo Watanabe
Feb 26, 2021·Canadian Journal of Gastroenterology & Hepatology·Gordana Kenđel JovanovićSanja Klobučar Majanović
Feb 20, 2021·Journal of Clinical and Translational Hepatology·Muhammad Masroor, Zeba Haque
Jul 25, 2021·International Journal of Molecular Sciences·Chunye Zhang, Ming Yang
Aug 23, 2019·Biochemistry·Jon R BeckCliff I Stains