Anthropometric and blood parameters for the prediction of NAFLD among overweight and obese adults

BMC Gastroenterology
Tilman KühnJohanna Nattenmüller

Abstract

Non-alcoholic fatty liver disease (NAFLD) comprises non-progressive steatosis and non-alcoholic steatohepatitis (NASH), the latter of which may cause cirrhosis and hepatocellular carcinoma (HCC). As NAFLD detection is imperative for the prevention of its complications, we evaluated whether a combination of blood-based biomarkers and anthropometric parameters can be used to predict NAFLD among overweight and obese adults. 143 overweight or obese non-smokers free of diabetes (50% women, age: 35-65 years) were recruited. Anthropometric indices and routine biomarkers of metabolism and liver function were measured to predict magnetic resonance (MR) - derived NAFLD by multivariable logistic regression models. In addition, we evaluated to which degree the use of more novel biomarkers (adiponectin, leptin, resistin, C-reactive protein, TNF-α, IL-6, IL-8 and interferon-γ) could improve prediction models. NAFLD was best predicted by a combination of age, sex, waist circumference, ALT, HbA1c, and HOMA-IR at an area under the receiver operating characteristic curve (AUROC) of 0.87 (95% CI: 0.81, 0.93) before and 0.85 (95% CI: 0.78, 0.91) after internal bootstrap validation. The use of additional biomarkers of inflammation and metabolism di...Continue Reading

References

Sep 2, 2004·American Journal of Physiology. Endocrinology and Metabolism·Lidia S SzczepaniakRobert L Dobbins
Jun 16, 2009·Gastroenterology·Anna KotronenHannele Yki-Järvinen
Sep 22, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Jeong-Hoon LeeHyo-Suk Lee
May 13, 2010·Digestive Diseases·Beate Katharina Straub, Peter Schirmacher
Aug 27, 2010·BMC Gastroenterology·Giorgio BedogniClaudio Tiribelli
Jul 20, 2011·Journal of Magnetic Resonance Imaging : JMRI·Geraldine H KangClaude B Sirlin
Apr 3, 2013·Genomics·Adviti NaikDamjana Rozman
Sep 18, 2013·Nature Reviews. Gastroenterology & Hepatology·Rohit Loomba, Arun J Sanyal
Sep 26, 2013·Nature Reviews. Gastroenterology & Hepatology·Laurent CasteraPaul Angulo
Dec 11, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xiaodong ZhongMustafa R Bashir
Aug 26, 2014·World Journal of Gastroenterology : WJG·Emer Fitzpatrick, Anil Dhawan
Sep 23, 2014·BMJ : British Medical Journal·Naveed SattarDavid Preiss
Jan 13, 2015·Canadian Journal of Gastroenterology & Hepatology·Manuela G NeumanRadu M Nanau
Apr 29, 2015·Journal of Hepatology·Christopher D Byrne, Giovanni Targher
Dec 1, 2013·Hepatology International·Ajay Duseja, Naga Chalasani
Apr 6, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michelle T LongCaroline S Fox
Apr 12, 2016·Clinics in Liver Disease·William N Hannah, Stephen A Harrison
May 18, 2016·International Journal of Molecular Sciences·Claudia SannaElisabetta Bugianesi
Jan 1, 2015·Nature Reviews. Disease Primers·Elizabeth M BruntMary E Rinella
Oct 1, 2016·World Journal of Gastroenterology : WJG·Laurence J BrittonDarrell Hg Crawford
Dec 6, 2016·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S HeebøllA Handberg

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Citations

Apr 26, 2019·Nutrients·Yixin JiangJohanna Nattenmüller
Apr 5, 2020·Nutrients·Cora WatzingerTilman Kühn
May 28, 2020·Nutrients·Manuela SpurnyJohanna Nattenmüller
Aug 23, 2020·Antioxidants·Margalida Monserrat-MesquidaAntoni Sureda
Oct 4, 2020·Diabetes/metabolism Research and Reviews·Francisca Dos Santos CoelhoAdelino Leite-Moreira
Apr 5, 2020·Experimental and Molecular Pathology·Shusei YamamotoShogo Watanabe
Feb 26, 2021·Canadian Journal of Gastroenterology & Hepatology·Gordana Kenđel JovanovićSanja Klobučar Majanović
Feb 20, 2021·Journal of Clinical and Translational Hepatology·Muhammad Masroor, Zeba Haque
Jul 25, 2021·International Journal of Molecular Sciences·Chunye Zhang, Ming Yang

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Methods Mentioned

BETA
blood draw
hormone replacement therapy
biopsies
biopsy

Clinical Trials Mentioned

NCT02449148

Software Mentioned

OsiriX

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