Anthropometric approaches and their uncertainties to assigning computational phantoms to individual patients in pediatric dosimetry studies

Physics in Medicine and Biology
Scott WhalenWesley E Bolch

Abstract

Current efforts to reconstruct organ doses in children undergoing diagnostic imaging or therapeutic interventions using ionizing radiation typically rely upon the use of reference anthropomorphic computational phantoms coupled to Monte Carlo radiation transport codes. These phantoms are generally matched to individual patients based upon nearest age or sometimes total body mass. In this study, we explore alternative methods of phantom-to-patient matching with the goal of identifying those methods which yield the lowest residual errors in internal organ volumes. Various thoracic and abdominal organs were segmented and organ volumes obtained from chest-abdominal-pelvic (CAP) computed tomography (CT) image sets from 38 pediatric patients ranging in age from 2 months to 15 years. The organs segmented included the skeleton, heart, kidneys, liver, lungs and spleen. For each organ, least-squared regression lines, 95th percentile confidence intervals and 95th percentile prediction intervals were established as a function of patient age, trunk volume, estimated trunk mass, trunk height, and three estimates of the ventral body cavity volume based on trunk height alone, or in combination with circumferential, width and/or breadth measurem...Continue Reading

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Sep 6, 2006·Physics in Medicine and Biology·Choonik LeeWesley E Bolch
Aug 1, 2007·Physics in Medicine and Biology·Choonsik LeeWesley E Bolch

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Citations

Oct 8, 2014·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Willi A KalenderBernhard Schmidt
Dec 30, 2009·Radiation and Environmental Biophysics·Wesley BolchPerry Johnson
Jun 19, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Alexandra ZverevaKatia Parodi
Jan 6, 2012·Physics in Medicine and Biology·Audrey Nadège Ilembe BadounaIbrahima Diallo
Apr 28, 2016·Physics in Medicine and Biology·Xiaoyu TianEhsan Samei
Mar 7, 2012·Journal of Nuclear Medicine Technology·Frederic H FaheyS James Adelstein

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