PMID: 16614405Apr 15, 2006Paper

Anthropometrics provide a better estimate of urinary organic acid anion excretion than a dietary mineral intake-based estimate in children, adolescents, and young adults

The Journal of Nutrition
Shoma Berkemeyer, Thomas Remer

Abstract

The role of elevated net endogenous acid production (NEAP) in the causation of osteoporosis, muscle wasting, and kidney stones is currently under discussion. The aim of this study was to examine whether urinary organic acid anion excretion, a major component of NEAP, is predicted primarily by anthropometric- (OA(anthro)) or diet- (OA(diet)) based estimates. Dietary intakes, anthropometric data, and 24-h urinary excretion rates of organic acids (24h-OA(urine)) were determined cross sectionally in healthy children (6-7 y; n = 217), adolescents (13-14 y; n = 91), and young adults (18-22 y; n = 82). OA(anthro) was computed from body surface area and OA(diet) calculated using a published algorithm based on dietary intakes of mineral anions and cations. There was a significant increase (P < 0.0001) in 24h-OA(urine) across the age groups that was no longer discernible after correction for body surface area. In almost all sex-stratified subsamples, OA(anthro) had a higher correlation with 24h-OA(urine) than OA(diet). Multiple regression analyses, using energy-corrected diet variables, revealed that OA(anthro) was consistently the primary predictor of 24h-OA(urine) (R(2) varying from 0.15 to 0.39) and dietary fat and protein were sporad...Continue Reading

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Sep 24, 2008·Journal of the American Geriatrics Society·Shoma BerkemeyerThomas Remer
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