Anti-37kDa antibodies are associated with the development of IDDM in individuals with islet cell antibodies

J C Ongagna, C Lévy-Marchal


Antibodies directed against a beta-cell specific antigen with a molecular weight of 37 kDa have recently been described. These anti-37kDa antibodies were measured by the immunoprecipitation technique in individuals at risk for insulin-dependent diabetes mellitus (IDDM), with islet cell antibodies (ICA) greater than 20 Juvenile Diabetes Foundation units (JDFU). These subjects were recruited from large population-based cohorts at various degrees of risk for developing the disease before adulthood. Anti-37kDa antibodies were measured in 25 ICA-positive first degree relatives with ICA greater than 20 JDFU, identified from a baseline cohort of 1,185 relatives (age: 0-75 years). Four relatives were positive for anti-37kDa antibodies since the first determination onwards. These relatives developed IDDM in a 2-year follow-up period. We included 300 children with an IDDM parent, and aged less than 7 years, in a prospective survey for the prediction of IDDM. Five (1.6%) showed ICA greater than 20 JDFU. None of them were found to be positive for anti-37kDa antibodies, and none have progressed to diabetes during a 2-year follow-up. Among a baseline cohort of 13,380 schoolchildren (age: 6-17 years), 28 (0.2%) were found to have ICA greater ...Continue Reading


Jul 31, 1998·Trends in Neurosciences·F M Ashcroft, F M Gribble
Oct 1, 1996·European Journal of Clinical Investigation·M R Christie
Feb 16, 2000·Ophthalmic Plastic and Reconstructive Surgery·J M Facciani, M Kazim


Jun 1, 1992·Diabetologia·C Lévy-MarchalP Czernichow
Sep 1, 1990·The Journal of Experimental Medicine·M R ChristieT L Delovitch
Aug 1, 1990·Diabetologia·C Lévy-MarchalP Czernichow
Mar 1, 1987·The Journal of Clinical Investigation·S BaekkeskovF Lindgren
Jul 1, 1985·Diabetologia·A MustonenH K Akerblom
Jan 1, 1993·Diabetes Care·P J BingleyE A Gale

Related Concepts

Incidence Studies
Islet cell surface antibodies
Phosphoglycerate Dehydrogenase Activity
Specific antigen
Islet Cell
PHGDH wt Allele
Diabetes Mellitus, Insulin-Dependent
Diabetes, Autoimmune

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.