Anti-A in factor VIII concentrate: a cause of severe hemolysis in a patient with acquired factor VIII:C antibodies

Infusionstherapie : offizielles Organ der Deutschen Arbeitsgemeinschaft für Künstliche Ernährung (DAKE) ; offizielles Organ der Österreichischen Arbeitsgemeinschaft für Klinische Ernähru (AKE) ; offizielles Organ der Deutschen Gesellschaft für Transfusion
V Hach-WunderleI Scharrer

Abstract

The authors report a case of acute macrohematuria in a patient with spontaneously acquired antibodies against factor VIII:C. Severe hemolysis was observed under factor VIII concentrate therapy. In 4 batches of the factor VIII concentrate high titers up to 1:512 of 'immune' anti-A were found. Clotting factor preparations used for replacement therapy, therefore, should be investigated for iso-antibodies, at least in situations where an intensive infusion therapy is required.

Citations

Feb 17, 2005·Biologicals : Journal of the International Association of Biological Standardization·Christoph BuchtaPaul Höcker

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