Anti-acetylcholinesterase and Antioxidant Activities of Inhaled Juniper Oil on Amyloid Beta (1-42)-Induced Oxidative Stress in the Rat Hippocampus

Neurochemical Research
Oana CioancaLucian Hritcu

Abstract

Juniper volatile oil is extracted from Juniperus communis L., of the Cupressaceae family, also known as common juniper. Also, in aromatherapy the juniper volatile oil is used against anxiety, nervous tension and stress-related conditions. In the present study, we identified the effects of the juniper volatile oil on amyloid beta (1-42)-induced oxidative stress in the rat hippocampus. Rats received a single intracerebroventricular injection of amyloid beta (1-42) (400 pmol/rat) and then were exposed to juniper volatile oil (200 μl, either 1 or 3 %) for controlled 60 min period, daily, for 21 continuous days. Also, the antioxidant activity in the hippocampus was assessed using superoxide dismutase, glutathione peroxidase and catalase specific activities, the total content of the reduced glutathione, protein carbonyl and malondialdehyde levels. Additionally, the acetylcholinesterase activity in the hippocampus was assessed. The amyloid beta (1-42)-treated rats exhibited the following: increase of the acetylcholinesterase, superoxide dismutase and catalase specific activities, decrease of glutathione peroxidase specific activity and the total content of the reduced glutathione along with an elevation of malondialdehyde and protein ...Continue Reading

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Citations

Aug 18, 2017·Journal of Cellular and Molecular Medicine·Paula Alexandra PostuLucian Hritcu
Oct 7, 2019·Chemistry & Biodiversity·Karolina A Wojtunik-KuleszaAnna Oniszczuk
Sep 16, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martina BottoniGelsomina Fico
May 23, 2019·Frontiers in Neurology·Sandip T Auti, Yogesh A Kulkarni

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