Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue.

Cellular and Molecular Life Sciences : CMLS
Tiziana CaputoFederica Gilardi

Abstract

Chronic inflammation that affects primarily metabolic organs, such as white adipose tissue (WAT), is considered as a major cause of human obesity-associated co-morbidities. However, the molecular mechanisms initiating this inflammation in WAT are poorly understood. By combining transcriptomics, ChIP-seq and modeling approaches, we studied the global early and late responses to a high-fat diet (HFD) in visceral (vWAT) and subcutaneous (scWAT) AT, the first being more prone to obesity-induced inflammation. HFD rapidly triggers proliferation of adipocyte precursors within vWAT. However, concomitant antiadipogenic signals limit vWAT hyperplastic expansion by interfering with the differentiation of proliferating adipocyte precursors. Conversely, in scWAT, residing beige adipocytes lose their oxidizing properties and allow storage of excessive fatty acids. This phase is followed by tissue hyperplastic growth and increased angiogenic signals, which further enable scWAT expansion without generating inflammation. Our data indicate that scWAT and vWAT differential ability to modulate adipocyte number and differentiation in response to obesogenic stimuli has a crucial impact on the different susceptibility to obesity-related inflammation ...Continue Reading

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Datasets Mentioned

BETA
GSE132885

Methods Mentioned

BETA
RNA-seq
RNAseq
acetylation
ChIP-seq
ChIPseq
histone acetylation
immunoprecipitation
ChIP
FCS
dissection

Key Resources (RRID) Mentioned

AB_306847
AB_2118291
AB_2167642
AB_2734986
AB_465632
AB_10670099
AB_465022
AB_493273
AB_2313786
AB_1140040

Software Mentioned

R
edge R pipeline
Prism
metaboGSE
WGCNA R package
RUVr R package
Ensemble
ClusterProfiler
CHANCE
mathop

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