Anti-Ageing Effect of Physalis alkekengi Ethyl Acetate Layer on a d-galactose-Induced Mouse Model through the Reduction of Cellular Senescence and Oxidative Stress

International Journal of Molecular Sciences
Kaiyue SunZijiao Guo

Abstract

We aimed to study the effects of an ethyl acetate fraction of Physalis alkekengi (PAE) on d-galactose (d-gal)-induced senescence and the underlying mechanism. Firstly, analysis of the phytochemical composition revealed total flavonoids, total phenolics, total saponins, rutin, and luteolin contents of 71.72 ± 2.99 mg rutin equivalents/g, 40.19 ± 0.47 mg gallic acid equivalents/g, 128.13 ± 1.04 mg oleanolic acid equivalents/g, 1.67 ± 0.07 mg/g and 1.61 ± 0.01 mg/g, respectively. The mice were treated with d-gal for six weeks, and from the fifth week, the mice were administered with PAE by gavage once a day for five weeks. We found significant d-gal-induced ageing-related changes, such as learning and memory impairment in novel object recognition and Y-maze, fatigue in weight-loaded forced swimming, reduced thymus coefficient, and histopathological injury of the liver, spleen, and hippocampus. The PAE effectively protected from such changes. Further evaluation showed that PAE decreased the senescence-associated β-galactosidase of the liver, spleen, and hippocampus, as well as the oxidative stress of the liver, plasma, and brain. The abundance of flavonoids, phenols, and saponins in PAE may have contributed to the above results. Ov...Continue Reading

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Abhishek Chandra, Jyotika Rajawat
Mar 13, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Min-Soo KimWon Kyung Jeon
Apr 28, 2021·Experimental Gerontology·Khairunnuur Fairuz AzmanRahimah Zakaria
Jul 25, 2021·International Journal of Molecular Sciences·Nagarajan MaharajanGwang-Won Cho

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